Synaptic specificity, recognition molecules, and assembly of neural circuits
JR Sanes, SL Zipursky - Cell, 2020 - cell.com
Developing neurons connect in specific and stereotyped ways to form the complex circuits
that underlie brain function. By comparison to earlier steps in neural development, progress …
that underlie brain function. By comparison to earlier steps in neural development, progress …
Generating and using transcriptomically based retinal cell atlases
It has been known for over a century that the basic organization of the retina is conserved
across vertebrates. It has been equally clear that retinal cells can be classified into …
across vertebrates. It has been equally clear that retinal cells can be classified into …
[HTML][HTML] Single-cell profiles of retinal ganglion cells differing in resilience to injury reveal neuroprotective genes
Neuronal types in the central nervous system differ dramatically in their resilience to injury or
other insults. Here we studied the selective resilience of mouse retinal ganglion cells …
other insults. Here we studied the selective resilience of mouse retinal ganglion cells …
Molecular classification and comparative taxonomics of foveal and peripheral cells in primate retina
High-acuity vision in primates, including humans, is mediated by a small central retinal
region called the fovea. As more accessible organisms lack a fovea, its specialized function …
region called the fovea. As more accessible organisms lack a fovea, its specialized function …
Evolution of neuronal cell classes and types in the vertebrate retina
The basic plan of the retina is conserved across vertebrates, yet species differ profoundly in
their visual needs. Retinal cell types may have evolved to accommodate these varied needs …
their visual needs. Retinal cell types may have evolved to accommodate these varied needs …
Unified classification of mouse retinal ganglion cells using function, morphology, and gene expression
Classification and characterization of neuronal types are critical for understanding their
function and dysfunction. Neuronal classification schemes typically rely on measurements of …
function and dysfunction. Neuronal classification schemes typically rely on measurements of …
[HTML][HTML] Transcriptional programs of circuit assembly in the Drosophila visual system
Precise patterns of synaptic connections between neurons are encoded in their genetic
programs. Here, we use single-cell RNA sequencing to profile neuronal transcriptomes at …
programs. Here, we use single-cell RNA sequencing to profile neuronal transcriptomes at …
Novel insights from a multiomics dissection of the Hayflick limit
The process wherein dividing cells exhaust proliferative capacity and enter into replicative
senescence has become a prominent model for cellular aging in vitro. Despite decades of …
senescence has become a prominent model for cellular aging in vitro. Despite decades of …
[HTML][HTML] Linking transcriptomes with morphological and functional phenotypes in mammalian retinal ganglion cells
Retinal ganglion cells (RGCs) are the brain's gateway to the visual world. They can be
classified into different types on the basis of their electrophysiological, transcriptomic, or …
classified into different types on the basis of their electrophysiological, transcriptomic, or …
Molecular classification of zebrafish retinal ganglion cells links genes to cell types to behavior
Y Kölsch, J Hahn, A Sappington, M Stemmer… - Neuron, 2021 - cell.com
Retinal ganglion cells (RGCs) form an array of feature detectors, which convey visual
information to central brain regions. Characterizing RGC diversity is required to understand …
information to central brain regions. Characterizing RGC diversity is required to understand …