Nuclear receptors (NRs) are transcription factors actively involved in many aspects of human
physiology and pathology, serving as sensors of stimuli, master regulators of downstream …

Estrogens have been implicated in the pathogenesis of various cancer types, including
colorectal carcinoma (CRC). Estrogen receptors such as ERα and ERβ activate intracellular …

Chronic inflammation of the colon (colitis) is a risk factor for colorectal cancer (CRC).
Hormone‐replacement therapy reduces CRC incidences, and the estrogen receptor beta …

Estrogen hormones protect against colorectal cancer (CRC) and a preventative role of
estrogen receptor beta (ERβ) on CRC has been supported using full knockout animals …

Nuclear receptors (NRs) have historically been at the forefront of cancer research, where
they are known to act as critical regulators of disease. They also serve as biomarkers for …

EMT represents the dominant program within advanced stages of colon cancer, where cells
acquire migratory characteristics in order to invade secondary tissues and form metastasis …

Estrogen is a kind of steroid compound that has extensive biologic activities. The effect of
estrogen is pleiotropic, affecting multiple systems in the body. There is accumulating …

microRNAs (miRNAs) are a class of small non-coding RNAs that regulate the expression of
their target mRNAs post transcriptionally. miRNAs are known to regulate not just a gene but …

There is a strong association between obesity and colorectal cancer (CRC), especially in
men, whereas estrogen protects against both the metabolic syndrome and CRC. Colon is …

The discovery of the Estrogen Receptor Beta (ERβ) in 1996 opened new perspectives in the
diagnostics and therapy of different types of cancer. Here, we present a review of the present …