A large body of experimental evidence suggests that neuroinflammation is a key
pathological event triggering and perpetuating the neurodegenerative process associated …

Occupational or environmental exposure to manganese (Mn) can lead to the development of
“Manganism,” a neurological condition showing certain motor symptoms similar to …

Metals play important roles in the human body, maintaining cell structure and regulating
gene expression, neurotransmission, and antioxidant response, to name a few. However …

Hayes' Principles and Methods of Toxicology has long been established as a reliable and
informative reference for the concepts, methodologies, and assessments integral to …

Manganese, an essential trace metal, is supplied to the brain via both the blood–brain and
the blood–cerebrospinal fluid barriers. There are some mechanisms in this process and …

Manganese is an essential trace element and it is required for many ubiquitous enzymatic
reactions. While manganese deficiency rarely occurs in humans, manganese toxicity is …

Quercetin, one of the major flavonoids in plants, has been recently reported to have
neuroprotective effects against neurodegenerative processes. However, since the molecular …

Parkinson's disease (PD) is the second most prevalent age-related neurodegenerative
disease with physiological manifestations including tremors, bradykinesia, abnormal …

The isoforms of the PKC family are activated in response to mitogenic stimuli, to
inflammatory stimuli, and to stress and play important roles in a variety of cellular functions …

Rottlerin has been used as a protein kinase Cδ (PKCδ)-selective inhibitor in hundreds of
studies, on the basis of initial substrate phosphorylation studies in vitro. However, in more …