Molecular mechanisms of astaxanthin as a potential neurotherapeutic agent

EI Bahbah, S Ghozy, MS Attia, A Negida, TB Emran… - Marine drugs, 2021 - mdpi.com
Neurological disorders are diseases of the central and peripheral nervous system that affect
millions of people, and the numbers are rising gradually. In the pathogenesis of …

Neuroprotective and immunomodulatory action of the endocannabinoid system under neuroinflammation

LA Kasatkina, S Rittchen, EM Sturm - International Journal of Molecular …, 2021 - mdpi.com
Endocannabinoids (eCBs) are lipid-based retrograde messengers with a relatively short half-
life that are produced endogenously and, upon binding to the primary cannabinoid receptors …

Cashew (Anacardium occidentale L.) Nuts Counteract Oxidative Stress and Inflammation in an Acute Experimental Model of Carrageenan-Induced Paw Edema

M Cordaro, R Siracusa, R Fusco, R D'Amico… - Antioxidants, 2020 - mdpi.com
Background: Anacardium occidentale L. is a medicinal plant with powerful anti-oxidative and
anti-inflammatory properties. Acute inflammatory events cause tissue alterations, decrease …

Açai berry mitigates vascular dementia-induced neuropathological alterations modulating Nrf-2/Beclin1 pathways

D Impellizzeri, R D'Amico, R Fusco, T Genovese… - Cells, 2022 - mdpi.com
The second-most common cause of dementia is vascular dementia (VaD). The majority of
VaD patients experience cognitive impairment, which is brought on by oxidative stress and …

Key Mechanisms and Potential Implications of Hericium erinaceus in NLRP3 Inflammasome Activation by Reactive Oxygen Species during Alzheimer's Disease

M Cordaro, AT Salinaro, R Siracusa, R D'Amico… - Antioxidants, 2021 - mdpi.com
Alzheimer's disease (AD) is the principal cause of dementia, and its incidence increases
with age. Altered antioxidant systems and inflammation have an important role in the …

The Role of Cashew (Anacardium occidentale L.) Nuts on an Experimental Model of Painful Degenerative Joint Disease

R Fusco, R Siracusa, AF Peritore, E Gugliandolo… - Antioxidants, 2020 - mdpi.com
Osteoarthritis is a progressive joint disease characterized by the activation of different
molecular mediators, including proinflammatory cytokines, reactive oxygen species …

ALIAmides update: palmitoylethanolamide and its formulations on management of peripheral neuropathic pain

R D'Amico, D Impellizzeri, S Cuzzocrea… - International journal of …, 2020 - mdpi.com
Neuropathic pain results from lesions or diseases of the somatosensory nervous system and
it remains largely difficult to treat. Peripheral neuropathic pain originates from injury to the …

The neuroprotective effects of micronized PEA (PEA‐m) formulation on diabetic peripheral neuropathy in mice

D Impellizzeri, AF Peritore, M Cordaro… - The FASEB …, 2019 - Wiley Online Library
Diabetic peripheral neuropathy (DPN) is a complication of diabetes connected with
morbidity and mortality. DPN presents deterioration of peripheral nerves with pain …

Açai berry mitigates Parkinson's disease progression showing dopaminergic neuroprotection via nrf2-HO1 pathways

R D'Amico, D Impellizzeri, T Genovese, R Fusco… - Molecular …, 2022 - Springer
The current pharmacological treatment for Parkinson's disease (PD) is focused on symptom
alleviation rather than disease prevention. In this study, we look at a new strategy to …

Discovering the effects of fisetin on NF-κB/NLRP-3/NRF-2 molecular pathways in a mouse model of vascular dementia induced by repeated bilateral carotid occlusion

M Cordaro, R D'Amico, R Fusco, AF Peritore… - Biomedicines, 2022 - mdpi.com
Vascular dementia (VaD) is the second leading cause of dementia. The majority of VaD
patients have cognitive abnormalities, which are caused by cerebral hypoperfusion-induced …