Uric acid is synthesized mainly in the liver, intestines and the vascular endothelium as the
end product of an exogenous pool of purines, and endogenously from damaged, dying and …

Purpose The aims of this article were to systematically review the literature about the
mechanism of action of colchicine in the multimodal pathology of acute inflammation …

Inflammation In the absence of pathogens occurs in all tissues in response to a wide range
of stimuli that cause tissue stress and injury. Such sterile inflammation (SI) is a key process …

Natural Abs, belonging to isotypes IgM, IgG3, and IgA, were discovered nearly half a century
ago. Despite knowledge about the role of the polyreactive natural IgM in pathogen …

The existence of IgM has been known for more than a century, but its importance in immunity
and autoimmunity continues to emerge. Studies of mice deficient in secreted IgM have …

Gout is a common crystal-induced arthritis, in which monosodium urate (MSU) crystals
precipitate within joints and soft tissues and elicit an inflammatory response. The causes of …

As an approved vaccine adjuvant for use in humans, alum has vast health implications, but,
as it is a crystal, questions remain regarding its mechanism. Furthermore, little is known …

Gout is an ancient disease that still plagues us. Its pathogenic culprit, uric acid crystal
deposition in tissues, is a strong inflammatory stimulant. In recent years, the mechanisms …

Uric acid (UA) is known to activate the NLRP3 (Nacht, leucine-rich repeat and pyrin domain
containing protein 3) inflammasome. When activated, the NLRP3 (also known as NALP3) …

Objective Deposition of monosodium urate monohydrate (MSU) crystals in the joints
promotes an intense inflammatory response and joint dysfunction. This study evaluated the …