Fanconi anaemia (FA) is a genetic disorder that is characterized by bone marrow failure
(BMF), developmental abnormalities and predisposition to cancer. Together with other …

Homologous recombination (HR) is a major pathway for the repair of DNA double-strand
breaks in mammalian cells, the defining step of which is homologous strand exchange …

Mutations in BRCA1 or BRCA2 (BRCA) is synthetic lethal with poly (ADP-ribose)
polymerase inhibitors (PARPi). Lethality is thought to derive from DNA double-stranded …

Germline mutations in BRCA1/2 predispose individuals to breast cancer (termed germline-
mutated BRCA1/2 breast cancer, gBRCA-BC) by impairing homologous recombination (HR) …

Fanconi anemia is a genetic disorder that is characterized by bone marrow failure, as well
as a predisposition to malignancies including leukemia and squamous cell carcinoma …

The function of Fanconi anaemia proteins is to maintain genomic stability. Their main role is
in the repair of DNA interstrand crosslinks, which, by covalently binding the Watson and the …

Mitotic homologous recombination promotes genome stability through the precise repair of
DNA double-strand breaks and other lesions that are encountered during normal cellular …

Cancer is fundamentally a disease of the genome and inherited deficiencies in DNA repair
pathways are well established to increase lifetime cancer risk. Computational analysis of …

PALB2 interacts with BRCA2, and biallelic mutations in PALB2 (also known as FANCN),
similar to biallelic BRCA2 mutations, cause Fanconi anemia. We identified monoallelic …

Helicases have major roles in genome maintenance by unwinding structured nucleic acids.
Their prominence is marked by various cancers and genetic disorders that are linked to …