Regulation of energy homeostasis by the NPY system
Obesity develops when energy intake exceeds energy expenditure over time. Numerous
neurotransmitters, hormones, and factors have been implicated to coordinately control …
neurotransmitters, hormones, and factors have been implicated to coordinately control …
The neuropeptide Y system: pathophysiological and therapeutic implications in obesity and cancer
L Zhang, MS Bijker, H Herzog - Pharmacology & therapeutics, 2011 - Elsevier
The neuropeptide Y (NPY) system–comprising of neuropeptide Y, peptide YY, pancreatic
polypeptide and the corresponding Y receptors through which they act (Y1, Y2, Y4, Y5 and …
polypeptide and the corresponding Y receptors through which they act (Y1, Y2, Y4, Y5 and …
Arcuate NPY controls sympathetic output and BAT function via a relay of tyrosine hydroxylase neurons in the PVN
YC Shi, J Lau, Z Lin, H Zhang, L Zhai, G Sperk… - Cell metabolism, 2013 - cell.com
Neuropepetide Y (NPY) is best known for its powerful stimulation of food intake and its
effects on reducing energy expenditure. However, the pathways involved and the regulatory …
effects on reducing energy expenditure. However, the pathways involved and the regulatory …
Macrophage inhibitory cytokine 1 (MIC-1/GDF15) decreases food intake, body weight and improves glucose tolerance in mice on normal & obesogenic diets
Food intake and body weight are controlled by a variety of central and peripheral factors, but
the exact mechanisms behind these processes are still not fully understood. Here we show …
the exact mechanisms behind these processes are still not fully understood. Here we show …
Amygdala NPY circuits promote the development of accelerated obesity under chronic stress conditions
Neuropeptide Y (NPY) exerts a powerful orexigenic effect in the hypothalamus. However,
extra-hypothalamic nuclei also produce NPY, but its influence on energy homeostasis is …
extra-hypothalamic nuclei also produce NPY, but its influence on energy homeostasis is …
Peripheral-specific Y1 receptor antagonism increases thermogenesis and protects against diet-induced obesity
Obesity is caused by an imbalance between food intake and energy expenditure (EE). Here
we identify a conserved pathway that links signalling through peripheral Y1 receptors (Y1R) …
we identify a conserved pathway that links signalling through peripheral Y1 receptors (Y1R) …
Probiotic treatment reduces appetite and glucose level in the zebrafish model
The gut microbiota regulates metabolic pathways that modulate the physiological state of
hunger or satiety. Nutrients in the gut stimulate the release of several appetite modulators …
hunger or satiety. Nutrients in the gut stimulate the release of several appetite modulators …
NPY receptors as potential targets for anti‐obesity drug development
E Yulyaningsih, L Zhang, H Herzog… - British journal of …, 2011 - Wiley Online Library
The neuropeptide Y system has proven to be one of the most important regulators of feeding
behaviour and energy homeostasis, thus presenting great potential as a therapeutic target …
behaviour and energy homeostasis, thus presenting great potential as a therapeutic target …
Diet-induced adaptive thermogenesis requires neuropeptide FF receptor-2 signalling
Excess caloric intake results in increased fat accumulation and an increase in energy
expenditure via diet-induced adaptive thermogenesis; however, the underlying mechanisms …
expenditure via diet-induced adaptive thermogenesis; however, the underlying mechanisms …
Y1 and Y5 receptors are both required for the regulation of food intake and energy homeostasis in mice
Neuropeptide Y (NPY) acting in the hypothalamus is one of the most powerful orexigenic
agents known. Of the five known Y receptors, hypothalamic Y1 and Y5 have been most …
agents known. Of the five known Y receptors, hypothalamic Y1 and Y5 have been most …