Human blood CD14+ monocytes are bone marrow–derived white blood cells that sense and
respond to pathogens. Although innate immune activation by RNA viruses preferentially …

Ferroptosis has emerged to be a promising approach in cancer therapies; however,
colorectal cancer (CRC) is relatively insensitive to ferroptosis. Exactly how the gut …

Introduction The four members of the p90 ribosomal S6 kinase (RSK) family are
serine/threonine protein kinases, which are phosphorylated and activated by ERK1/2 …

The cellular oncogene c-Fos (c-Fos) is a component of activator protein 1 (AP1), a master
transcriptional regulator of cells. The suppression of c-Fos signaling by siRNA treatment …

Jdp2 is an AP-1 family transcription factor that regulates the epigenetic status of histones.
Previous in vitro studies revealed that Jdp2 is involved in osteoclastogenesis. However, the …

Osteoclasts are multinucleated cells formed by fusion of mononuclear precursors in
response to receptor activator of nuclear factor κB (NF-κB) ligand (RANKL). We found that …

Objectives Assisted reproductive technology (ART) is an important part of reproductive
medicine, whose possible effects on offspring's health have drawn widespread attention in …

The intracellular parasite Salmonella enterica serovar Typhimurium causes a typhoid-like
systemic disease in mice. Whereas the survival of Salmonella in phagocytes is well …

Receptor tyrosine kinases are emerging as a class of key regulators of innate immune
responses. We have shown previously that the RON receptor tyrosine kinases (murine Stk) …

During vaccination or infection, adaptive and innate immune receptors of B cells are
engaged by microbial antigens/ligands. A better understanding of how innate and adaptive …