Anxiety and fear are evolutionarily conserved emotions that increase the likelihood of an
organism surviving threatening situations. Anxiety and vigilance states are regulated by …

Parkinson's disease (PD) is a common neurodegenerative disease in middle‐aged and
older adults. Abnormal proteins such as α‐synuclein are essential factors in PD's …

Abstract 3D cell cultures allow a better mimicry of the biological and mechanical
environment of cells in vivo compared to 2D cultures. However, 3D cell cultures have been …

Glycine receptors are ligand-gated chloride-selective channels that control excitability in the
central nervous system (CNS). Herein, we have investigated the mRNA expression of the …

Startle disease is due to the disruption of recurrent inhibition in the spinal cord. Most
common causes are genetic variants in genes (GLRA1, GLRB) encoding inhibitory glycine …

Abstract Aims Glycine receptors (GlyRs) are potentiated by physiologically relevant
concentrations of ethanol, and mutations in the intracellular loop of α1 and α2 subunits …

Glycine receptors (GlyRs) are ligand-gated chloride channels comprising alpha (α1–4) and
β subunits. The GlyR subunits play major roles in the mammalian central nervous system …

Startle disease (SD) is characterized by enhanced startle responses, generalized muscle
stiffness, unexpected falling, and fatal apnea episodes due to disturbed feedback inhibition …

Background: Ischemic stroke is mainly caused by cerebral artery thrombosis. This study
investigated the role of glycine receptor beta subunit (GlyR-β) in the recovery from cerebral …

Patients diagnosed with the rare autoimmune disease of Stiff Person Syndrome (SPS) suffer
from varying motor symptoms mainly characterized by painful spasms and muscle stiffness …