Polyunsaturated fatty acids and fatty acid-derived lipid mediators: Recent advances in the understanding of their biosynthesis, structures, and functions

SC Dyall, L Balas, NG Bazan, JT Brenna… - Progress in lipid …, 2022 - Elsevier
Polyunsaturated fatty acids (PUFAs) are structural components of membrane phospholipids,
and influence cellular function via effects on membrane properties, and also by acting as a …

Resolvins and cysteinyl-containing pro-resolving mediators activate resolution of infectious inflammation and tissue regeneration

CN Serhan, N Chiang - Prostaglandins & other lipid mediators, 2023 - Elsevier
This review is a synopsis of the main points from the opening presentation by the authors in
the Resolution of Inflammation session at the 8th European Workshop on Lipid Mediators …

Resolvin T-series reduce neutrophil extracellular traps

N Chiang, M Sakuma, AR Rodriguez… - Blood, The Journal …, 2022 - ashpublications.org
The newly identified 13-series (T-series) resolvins (RvTs) regulate phagocyte functions and
accelerate resolution of infectious inflammation. Because severe acute respiratory syndrome …

E-series resolvin metabolome, biosynthesis and critical role of stereochemistry of specialized pro-resolving mediators (SPMs) in inflammation-resolution: Preparing …

CN Serhan, S Libreros, R Nshimiyimana - Seminars in immunology, 2022 - Elsevier
The COVID-19 pandemic has raised international awareness of the importance of rigorous
scientific evidence and the havoc caused by uncontrolled excessive inflammation. Here we …

[HTML][HTML] Resolvin D2 and its receptor GPR18 in cardiovascular and metabolic diseases: A promising biomarker and therapeutic target

M Zhao, Z Zheng, Z Yin, J Zhang, J Qin, J Wan… - Pharmacological …, 2023 - Elsevier
Accumulating evidence suggests that inflammation plays an important role in the
pathophysiology of the initiation and progression of cardiovascular and metabolic diseases …

Specialized Pro-Resolving Lipid Mediators: Endogenous Roles and Pharmacological Activities in Infections

FS Rasquel-Oliveira, MDV Silva, G Martelossi-Cebinelli… - Molecules, 2023 - mdpi.com
During an infection, inflammation mobilizes immune cells to eliminate the pathogen and
protect the host. However, inflammation can be detrimental when exacerbated and/or …

Proresolving Lipid Mediators in the Respiratory System

CN Serhan, BD Levy - Annual Review of Physiology, 2024 - annualreviews.org
Lung inflammation, infection, and injury can lead to critical illness and death. The current
means to pharmacologically treat excessive uncontrolled lung inflammation needs …

Role of miRNAs as biomarkers of COVID-19: A scoping review of the status and future directions for research in this field

MB Visacri, AS Nicoletti, EC Pincinato… - Biomarkers in …, 2021 - Taylor & Francis
Aim: miRNAs are potential biomarkers of several diseases. This review aimed to identify the
miRNAs that could serve as biomarkers of COVID-19. Materials & methods: A literature …

COVID-19 inflammation and implications in drug delivery

M Zoulikha, F Huang, Z Wu, W He - Journal of Controlled Release, 2022 - Elsevier
Growing evidence indicates that hyperinflammatory syndrome and cytokine storm observed
in COVID-19 severe cases are narrowly associated with the disease's poor prognosis …

The function of specialized pro-resolving endogenous lipid mediators, vitamins, and other micronutrients in the control of the inflammatory processes: Possible role in …

CG Gallo, S Fiorino, G Posabella, D Antonacci… - Prostaglandins & other …, 2022 - Elsevier
Inflammation is an essential protective response against harmful stimuli, such as invading
pathogens, damaged cells, or irritants. Physiological inflammation eliminates pathogens and …