Abstract Iron-sulfur (Fe–S) clusters are essential cofactors most commonly known for their
role mediating electron transfer within the mitochondrial respiratory chain. The Fe–S cluster …

A persistently patent ductus arteriosus (PDA) in preterm infants can have significant clinical
consequences, particularly during the recovery period from respiratory distress syndrome …

Non-steroidal anti-inflammatory drugs (NSAIDs) are commonly prescribed in pregnancy to
treat fever, pain and inflammation. Indications for chronic use of these agents during …

Patent ductus arteriosus (PDA) is one of the most common congenital heart defects,
accounting for 5%–10% of all congenital heart disease in term infants. The occurrence of …

Failure of ductus arteriosus closure after preterm birth is associated with significant
morbidities. Ductal closure requires and is regulated by a complex interplay of molecular …

Background—Constriction of the ductus arteriosus (DA) is initiated at birth by inhibition of O2-
sensitive K+ channels in DA smooth muscle cells. Subsequent membrane depolarization …

Closure of the ductus arteriosus at birth is a complex phenomenon being conditioned by
antenatal events and progressing in preprogrammed steps. Functional at first, narrowing of …

Rationale: Closure of the ductus arteriosus (DA) is essential for the transition from fetal to
neonatal patterns of circulation. Initial Po2-dependent vasoconstriction causes functional DA …

Localized alveolar hypoxia causes constriction of the small resistance pulmonary arteries,
thus diverting the desaturated, mixed-venous blood to better ventilated areas of the lung …

Voltage-gated K+ channels belonging to Kv1–9 subfamilies are widely expressed in
excitable cells where they play an essential role in membrane hyperpolarization during an …