Introduction Vaccination is so far the most effective way of eradicating infections. Rapidly
emerging drug resistance against infectious diseases and chemotherapy-related toxicities in …

Leishmaniasis is a group of disease caused by the intracellular protozoan parasite of the
genus Leishmania. Infection by different species of Leishmania results in various host …

Biological drugs are attracting tremendous attention in disease treatment. However, their
application is significantly limited by their inherent properties, such as high hydrophilicity …

Metabolic engineering of the tumor microenvironment has emerged as a new strategy.
Lactate dehydrogenase A (LDHA) is a prominent target for metabolic engineering. Here, we …

In this study, we sought to design a bionanomaterial that could exert anticancer effects
against primary tumors and protect against rechallenged tumors via photodynamic …

An attractive type of cancer immunotherapy is cancer therapeutic vaccines that induce
antitumor immunity effectively. Although supportive results in the recent vaccine studies …

Lack of vaccine and increasing chemotherapeutic toxicities currently necessitate the
development of effective and safe drugs against various forms of leishmaniases. We …

We designed a novel lyophilization method using controlled rate slow freezing (CSF) with
lyoprotective agent (LPA) to achieve intact lipid nanovesicles after lyophilization. During the …

Visceral leishmaniasis (VL) is a tropical disease that can be fatal if acute and untreated.
Diagnosis is difficult, the treatment is toxic and prophylactic vaccines do not exist …

Leishmaniasis refers to a plethora of vector-borne protozoan diseases clinically manifested
as self-healing cutaneous, mucocutaneous and most dangerous visceral forms, caused by …