Orofacial clefts (OFCs) rank as the second most common congenital birth defect in the
United States after Down syndrome and are the most common head and neck congenital …

Clefts of the lip and/or palate (CLP) are common birth defects of complex aetiology. CLP can
occur in isolation or as part of a broad range of chromosomal, Mendelian or teratogenic …

Orofacial clefts are common birth defects and can occur as isolated, nonsyndromic events or
as part of Mendelian syndromes. There is substantial phenotypic diversity in individuals with …

The mononuclear phagocytes control the body homeostasis through the involvement in
resolving tissue injury and further wound healing. Indeed, local tissue microenvironmental …

Isolated cleft palate (CPO) is the rarest form of oral clefting. The incidence of CPO varies
substantially by geography from 1.3 to 25.3 per 10,000 live births, with the highest rates in …

Clefts of the lip and palate are generally divided into two groups, isolated cleft palate and
cleft lip with or without cleft palate, representing a heterogeneous group of disorders …

Case-parent trios were used in a genome-wide association study of cleft lip with and without
cleft palate. SNPs near two genes not previously associated with cleft lip with and without …

There is considerable ambiguity in the use of terminology when referring to orofacial clefts
(OFCs). Many clinicians incorrectly refer to OFCs as deformities, which are said to be the …

The epithelial and mesenchymal cells involved in early embryonic facial development are
guided by complex regulatory mechanisms. Any factor perturbing the growth, approach and …

Orofacial clefts comprise a range of congenital deformities and are the most common head
and neck congenital malformation. Clefting has significant psychological and socio …