Inflammaging and anti-inflammaging: a systemic perspective on aging and longevity emerged from studies in humans
A large part of the aging phenotype, including immunosenescence, is explained by an
imbalance between inflammatory and anti-inflammatory networks, which results in the low …
imbalance between inflammatory and anti-inflammatory networks, which results in the low …
Two faces of p53: aging and tumor suppression
F Rodier, J Campisi, D Bhaumik - Nucleic acids research, 2007 - academic.oup.com
The p53 tumor suppressor protein, often termed guardian of the genome, integrates diverse
physiological signals in mammalian cells. In response to stress signals, perhaps the best …
physiological signals in mammalian cells. In response to stress signals, perhaps the best …
Transcription-independent pro-apoptotic functions of p53
Induction of apoptosis is one of the central activities by which p53 exerts its tumor-
suppressing function. Aside from its primary function as a transcription factor, it can promote …
suppressing function. Aside from its primary function as a transcription factor, it can promote …
Aging of the immune system as a prognostic factor for human longevity
A Larbi, C Franceschi, D Mazzatti, R Solana… - …, 2008 - journals.physiology.org
Accumulating data are documenting an inverse relationship between immune status,
response to vaccination, health, and longevity, suggesting that the immune system becomes …
response to vaccination, health, and longevity, suggesting that the immune system becomes …
WT p53, but not tumor-derived mutants, bind to Bcl2 via the DNA binding domain and induce mitochondrial permeabilization
Y Tomita, N Marchenko, S Erster, A Nemajerova… - Journal of Biological …, 2006 - ASBMB
The induction of apoptosis by p53 in response to cellular stress is its most conserved
function and crucial for p53 tumor suppression. We recently reported that p53 directly …
function and crucial for p53 tumor suppression. We recently reported that p53 directly …
p53 and Nur77/TR3–transcription factors that directly target mitochondria for cell death induction
UM Moll, N Marchenko, XK Zhang - Oncogene, 2006 - nature.com
The complex apoptotic functions of the p53 tumor suppressor are central to its antineoplastic
activity in vivo. Conversely, p53 function is altered or attenuated in one way or another in the …
activity in vivo. Conversely, p53 function is altered or attenuated in one way or another in the …
Immunoproteasome and LMP2 polymorphism in aged and Alzheimer's disease brains
In this study, we investigated the presence and role of immunoproteasome and its LMP2
subunit polymorphism at codon 60 in Alzheimer's disease (AD). Immunoproteasome was …
subunit polymorphism at codon 60 in Alzheimer's disease (AD). Immunoproteasome was …
Variation in the human TP53 gene affects old age survival and cancer mortality
Longevity may depend on a balance between tumor suppression and tissue renewal
mechanisms [Campisi, J., 2003. Cancer and ageing: rival demons? Nat. Rev. Cancer 3 (5) …
mechanisms [Campisi, J., 2003. Cancer and ageing: rival demons? Nat. Rev. Cancer 3 (5) …
Interleukin-1β causes excitotoxic neurodegeneration and multiple sclerosis disease progression by activating the apoptotic protein p53
S Rossi, C Motta, V Studer, G Macchiarulo… - Molecular …, 2014 - Springer
Background Understanding how inflammation causes neuronal damage is of paramount
importance in multiple sclerosis (MS) and in other neurodegenerative diseases. Here we …
importance in multiple sclerosis (MS) and in other neurodegenerative diseases. Here we …
The genetics of human longevity
M Capri, S Salvioli, F Sevini, S Valensin… - Annals of the New …, 2006 - Wiley Online Library
Aging is due to a complex interaction of genetic, epigenetic, and environmental factors, but a
strong genetic component appears to have an impact on survival to extreme ages. In order …
strong genetic component appears to have an impact on survival to extreme ages. In order …