Transforming growth factor β (TGF-β) plays an important role in normal development and
homeostasis. Dysregulation of TGF-β responsiveness and its downstream signaling …

FK506 binding (FKBP) proteins are part of the highly conserved immunophilin family and its
members have fundamental roles in the regulation of signalling pathways involved in …

Protein trafficking requires coat complexes that couple recognition of sorting motifs in
transmembrane cargoes with biogenesis of transport carriers. The mechanisms of cargo …

Transforming growth factor-beta2 (TGF-β2) is recognized as a versatile cytokine that plays a
vital role in regulation of joint development, homeostasis, and diseases, but its role as a …

In the 1980s, researchers used binding studies to show that there is a melatonin binding site
in addition to the receptors described previously. It was first termed ML2 and then, in 1999 …

Investigations of the human germline and programming are challenging because of limited
access to embryonic material. However, the pig as a model may provide insights into …

Abstract Introduction Mesenchymal stromal cells (MSCs) release extracellular vesicles (MSC-
EVs) containing various cargoes. Although MSC-EVs show significant therapeutic effects …

Activation of thermogenic brown and beige adipocytes is considered as a strategy to
improve metabolic control. Here, we identify GPR180 as a receptor regulating brown and …

Abstract Background and Aims Melatonin reduces biliary damage and liver fibrosis in
cholestatic models by interaction with melatonin receptors 1A (MT1) and 1B (MT2). MT1 and …

Cardiac fibrosis is a common irreversible pathological feature of diverse heart disorders.
Uncontrolled cardiac fibrosis contributes to maladaptive cardiac remodeling and eventually …