Lipases in asymmetric transformations: Recent advances in classical kinetic resolution and lipase–metal combinations for dynamic processes

ZS Seddigi, MS Malik, SA Ahmed… - Coordination Chemistry …, 2017 - Elsevier
The importance of chiral organic intermediates in various industrial sectors cannot be
underestimated. Lipases and their use in combination with metal catalysts is a promising …

Synthesis of enantiopure drugs and drug intermediates by immobilized lipase-catalysis

J Brabcova, M Filice, M Gutarra… - Current Bioactive …, 2013 - ingentaconnect.com
Enantiomerically pure product synthesis plays a key role in production of pharmaceuticals.
The application of biocatalytic approaches represents a convenient and sustainable way for …

Chemoenzymatic synthesis of optically active alcohols possessing 1, 2, 3, 4-tetrahydroquinoline moiety employing lipases or variants of the acyltransferase from …

B Zdun, I Kopińska, M Dranka, T Reiter, W Kroutil… - Catalysts, 2022 - mdpi.com
The enzymatic kinetic resolution (EKR) of racemic alcohols or esters is a broadly recognized
methodology for the preparation of these compounds in optically active form. Although EKR …

Kinetic resolution of β-substituted olefinic carboxylic acids by asymmetric bromolactonization

K Murai, T Matsushita, A Nakamura, N Hyogo… - Organic …, 2013 - ACS Publications
A strategically novel kinetic resolution of β-substituted olefinic carboxylic acids is developed
by asymmetric bromolactonization using an organocatalyst, 4-t BuPh-tris 1b. The cyclization …

Enantioselective Synthesis of 3-Aryl-3-hydroxypropanoic Esters as Subunits for Chiral Liquid Crystals

I Dokli, A Ozegovic, A Simanovic… - The Journal of …, 2022 - ACS Publications
Chiral liquid crystals (LCs) with their unique optical and mechanical properties are
perspective functional soft materials for fundamental science and advanced technological …

Molecular cloning and characterization of a thermostable esterase/lipase produced by a novel Anoxybacillus flavithermus strain

L Chiş, M Hriscu, A Bica, M Toşa, G Nagy… - The Journal of General …, 2013 - jstage.jst.go.jp
A thermophilic strain producing an extracellular esterase/lipase was isolated from a hot
spring in Tăşnad, Romania, and was identified phenotypically and by 16S rDNA sequencing …

Studies on the chemoenzymatic synthesis of (R)-and (S)-methyl 3-aryl-3-hydroxypropionates: the influence of toluene-pretreatment of lipase preparations on …

P Borowiecki, M Bretner - Tetrahedron: Asymmetry, 2013 - Elsevier
Two series (para-and meta-substituted) of racemic methyl esters of 3-aryl-3-
hydroxypropionic acid were prepared after which the enantiomers were separated by an …

Acylative kinetic resolution of racemic aromatic β-hydroxy esters catalyzed by chiral nucleophilic N-(1-arylethyl) benzoguanidines

A Yamada, K Nakata, I Shiina - Tetrahedron: Asymmetry, 2017 - Elsevier
An efficient acylative kinetic resolution of racemic aromatic β-hydroxy esters with
cyclohexanecarboxylic anhydride was achieved using newly designed (R)-N …

Access to optically pure β-hydroxy esters via non-enzymatic kinetic resolution by a planar-chiral DMAP catalyst

AE Díaz-Álvarez, L Mesas-Sánchez, P Dinér - Molecules, 2014 - mdpi.com
The development of new approaches to obtain optically pure β-hydroxy esters is an
important area in synthetic organic chemistry since they are precursors of other high value …

Evaluation of a new protocol for enzymatic dynamic kinetic resolution of 3-hydroxy-3-(aryl) propanoic acids

D Koszelewski, M Zysk, A Brodzka, A Żądło… - Organic & …, 2015 - pubs.rsc.org
The application of tandem metal–enzyme dynamic kinetic resolution (DKR) is a powerful tool
for the manufacture of high-value chemical commodities. A new protocol of kinetic resolution …