Gene therapy is extensively studied as a realistic and promising therapeutic approach for
treating inherited and acquired diseases by repairing defective genes through introducing …

The recent success of gene therapy during the COVID‐19 pandemic has underscored the
importance of effective and safe delivery systems. Complementing lipid‐based delivery …

Small interfering RNA (siRNA) can be exploited to silence specific genes associated with
cancer development, and successful siRNA therapy is highly dependent on the efficiency of …

While the rise of superbugs and new resistance mechanisms continues decreasing the
effectiveness of classical antibiotics, antimicrobial peptides (AMPs) are emerging as a new …

Background: Intravesical chemotherapy is highly recommended after transurethral resection
of bladder tumor for patients with bladder cancer (BCa). However, this localized adjuvant …

Nowadays, nucleic acid derivatives capable of modulating gene expression at the RNA level
have gained widespread recognition as promising therapeutic agents. A suitable degree of …

In recent years, nanoparticles (NPs) have been extensively developed as drug carriers to
overcome the limitations of cancer therapeutics. However, there are several biological …

Antiangiogenic therapy with sorafenib (SF) alone is ineffective in eradicating tumors, and its
long-term application can exacerbate tumor hypoxia, which in turn restricts SF's therapeutic …

Mesoporous silica nanoparticles (MSN) are emerging as one of the most appealing
candidates for gene carriers. Nevertheless, one major obstacle for their clinical application is …

摘要为了探究基于低分子量聚乙烯亚胺(polyethylenimine, PEI) 基因载体的转染效率,
通过Michael 加成反应将PEI 600 Da 接枝于含有疏水链的生物可降解聚酯上形成系列梳状聚合 …