During long standing hyperglycaemic state in diabetes mellitus, glucose forms covalent
adducts with the plasma proteins through a non-enzymatic process known as glycation …

Non-enzymatic reaction involving carbonyl of reducing sugars and amino groups in proteins
produces advanced glycation end products (AGEs). AGE accumulation in vivo is a crucial …

Background Advanced glycation end-products (AGEs) and their interaction with the receptor
for advanced glycation end-products (RAGE) play a pivotal role in the development and …

The discovery of the receptor for advanced glycation end-products (RAGE) set the stage for
the elucidation of important mechanisms underpinning diabetic complications. RAGE …

Background: Diabetic peripheral neuropathy (DPN) is known to predict foot ulceration, lower-
extremity amputation and mortality. Patients with diabetes mellitus have a predisposition …

This comprehensive review of the literature aimed to investigate the interplay between the
oral microbiome, oral cavity conditions, and host immune response in Diabetes mellitus …

The multi-ligand receptor RAGE was discovered on account of its ability to bind and
transduce the cell stress-provoking signals of advanced glycation endproducts (AGEs). The …

Background Multiple pathogenetic mechanisms are involved in the genesis of various
microvascular and macrovascular complications of diabetes mellitus. Of all these, advanced …

Diabetic peripheral neuropathy (DPN) is a common complication of diabetes that is
associated with axonal atrophy, demyelination, blunted regenerative potential, and loss of …

There is growing evidence that chronic hyperglycemia leads to the formation of advanced
glycation end products (AGEs) which exerts its effect via interaction with the receptor for …