Oxidative stress due to imbalance between ROS production and detoxification plays a
pivotal role in determining cell fate. In response to the excessive ROS, apoptotic signaling …

Peroxiredoxins (PRDX s), a ubiquitous family of redox‐regulating proteins, are reported of
potential to eliminate various reactive oxygen species (ROS). As a major member of the …

Esophageal cancer (EC) is a type of aggressive cancer without clinically relevant molecular
subtypes, hindering the development of effective strategies for treatment. To define …

Background Hypoxic microenvironment of colon cancer is associated with HIF-1α
upregulation. HIF-1α response elements are responsible for autophagy induction that …

Fat-soluble vitamins (vitamin A, D, E, and K) assume a pivotal role in maintaining human
homeostasis by virtue of their enzymatic functions. The daily inclusion of these vitamins is …

Tumor recurrence and metastasis decrease the survival rate of colorectal cancer (CRC)
patients. Menadione reduces the numbers and incidences of 1, 2-dimethylhydrazine …

Fuchs endothelial corneal dystrophy (FECD) is a genetic and oxidative stress disorder of
post-mitotic human corneal endothelial cells (HCEnCs), which normally exhibit hexagonal …

Epidemiological studies have demonstrated a relationship between cancer incidence and
dietary habits. Especially intake of certain essential nutrients like vitamins has been shown …

Wnt signaling is involved in the regulation of cell proliferation, differentiation and apoptosis.
Its aberrant activation is a key event in the pathogenesis and progression of human …

Background: 1, 4-naphthoquinones, especially juglone, are known for their anticancer
activity. However, plumbagin, lawsone, and menadione have been less investigated for …