Background Iron overload can result in grave consequences in thalassemic patients, despite
the availability of iron chelators. Therefore, alternative pathways aiming to reduce iron …

Thalassemia is a genetic disease characterized by iron overload which is a major
detrimental factor contributing to mortality and organ damage. The hepcidin secreted by liver …

Since iron overload is the commonest cause of morbidity and mortality in β thalassemia
major (β-TM), it represents one major target in therapeutic management of the disease. The …

The aim of our study was to analyze the role of toll-like receptor 4 (TLR4)/nuclear factor (NF)-
κB signal pathway on Hepcidin regulation in non‑alcoholic fatty liver disease (NAFLD). A …

Objective To evaluate the efficacy of deferiprone (DFP), 1-(N-acetyl-6-aminohexyl)-3-
hydroxy-2-methylpyridin-4-one (CM1) or green tea extract (GTE) in enhancing expression of …

Iron loading is regarded as the primary cause of endocrine abnormalities in thalassemia
major patients. Thus, the purpose of the current research was to explore the impact of …

Background: β thalassemia patients have repeated blood transfusions those lead to iron
overload, resulting in iron toxicity. In such cases Hepcidin results in excessive iron …

Iron overload is the main cause of morbidity and mortality in β-thalassemia major patients,
and cardiac iron overload is the most common reason for death in these transfusion …

Iron overload remains a major cause of morbidity and mortality among β-thalassemia major
(β-TM) patients. Iron regulatory proteins and their genetic variants together with changes in …

Background Cardiac iron overload is a common cause of death in thalassemia major and is
associated with hepcidin, which is primary iron homeostasis. Therapeutics that could …