Peroxisome proliferator-activated receptors (PPARs) are members of the nuclear hormone
receptor superfamily of ligand-activated transcription factors. Accumulating evidence …

In the last few decades, rapid changes in lifestyle have led to an alarming increase in the
prevalence of obesity and obesity-associated complications. Obese patients are at …

The interplays between the metabolic products of intestinal microbiota and the host
signaling through xenobiotic receptors, including pregnane X receptor (PXR), are of growing …

Peroxisome proliferator-activated receptors (PPARs) are a family of nuclear hormone
receptors that control the transcription of specific genes by binding to regulatory DNA …

Over the last 30 years, nuclear receptors (NRs) have been increasingly recognized as key
modulators of systemic homeostasis and as contributing factors in many diseases. In the …

Recent clinical studies have revealed that the serum levels of toxic hydrophobic bile acids
(deoxy cholic acid, lithocholic acid [LCA], and glycoursodeoxycholic acid) are significantly …

Triclosan (TCS) is a ubiquitous antimicrobial used in daily consumer products. Previous
reports have shown that TCS could induce hepatotoxicity, endocrine disruption, disturbance …

Background Maternal obesity is associated with dysregulation of glucose and lipid
metabolism with consequent exposure of the fetus to an abnormal metabolic milieu. It is …

Warfarin-induced vitamin K (VK) recycling impairment is used worldwide as a rodenticide
and human thromboembolic prophylactic. Since VK metabolism/signaling pathways have …

High plasma levels of lipids and/or lipoproteins are risk factors for atherosclerosis,
nonalcoholic fatty liver disease (NAFLD), obesity, and diabetes. These four conditions have …