The application of next generation sequencing (NGS) technology to cytological samples has
significantly modified molecular cytopathology practice. Cytological samples represent a …

Molecular cytopathology is a rapidly evolving field embracing both conventional microscopy
and molecular pathology. Its growing popularity stems from the fact that in many types of …

Tumor-specific, circulating cell-free DNA (cfDNA) in liquid biopsy test is a novel promising
biomarker in the advancement of cancer management, including early diagnosis, screening …

Background The use of RNA‐based next‐generation sequencing (NGS) assays to detect
gene fusions for targeted therapy has rapidly become an essential component of …

Highlights•Morphologic and molecular subtyping of non-small cell lung carcinoma, which
must often be performed on cytologic or small histologic biopsy specimens, is necessary for …

Liquid biopsy is a rapidly emerging field due to an increasing number of oncogenic drivers
and a better understanding of resistance mechanisms to targeted therapies in non-small cell …

Biomarker testing in patients with advanced stage non–small cell lung cancer provides
essential information that can be used to select the most appropriate therapy. The regular …

Bile duct brushing (BDB) is used to evaluate pancreatobiliary lesions as it widely samples
lesions with a low complication rate. Cytological evaluation of BDB is a specific but …

Objective Targeted therapy is an important part of the treatment of lung adenocarcinoma.
Tests for EGFR mutation, ALK, ROS1, RET and NTRK gene fusions are needed to make a …

This study aimed to investigate the prognostic significance of tumor mutation burden (TMB)
among patients with non-small cell lung cancer (NSCLC) who received platinum-based …