Calcium (Ca2+) is an essential signaling molecule that controls a wide range of biological
functions. In the immune system, calcium signals play a central role in a variety of cellular …

Calcium (Ca 2+) signals play fundamental roles in immune cell function. The main sources
of Ca 2+ influx in mammalian lymphocytes following antigen receptor stimulation are Ca 2+ …

Ion channels and transporters mediate the transport of charged ions across hydrophobic
lipid membranes. In immune cells, divalent cations such as calcium, magnesium, and zinc …

Sjogren's syndrome: An update on disease pathogenesis, clinical manifestations and treatment
Sjogren's syndrome: An update on disease pathogenesis, clinical manifestations and treatment …

Sjögren's syndrome (SjS) is a systemic autoimmune disease, characterized by the presence
of periductal lymphocytic infiltrations in salivary and lachrymal glands resulting in oral and …

In addition to susceptibility to infections, conventional primary immunodeficiency disorders
(PIDs) and inborn errors of immunity (IEI) can cause immune dysregulation, manifesting as …

Cellular homeostasis relies upon precise regulation of Ca2+ concentration. Stromal
interaction molecule (STIM) proteins regulate store-operated calcium entry (SOCE) by …

Plasma-membrane-localized Orai1 ion channel subunits interacting with ER-localized
STIM1 molecules comprise the major subunit composition responsible for calcium release …

Sjogren's syndrome is a common autoimmune disease that presents with sicca symptoms
and extraglandular features. Sjogren's syndrome is presumably as common as RA; yet it is …

T follicular helper (Tfh) cells promote affinity maturation of B cells in germinal centers (GCs),
whereas T follicular regulatory (Tfr) cells limit the GC reaction. Store-operated Ca 2+ entry …