Multiscale simulations of biological membranes: the challenge to understand biological phenomena in a living substance
Biological membranes are tricky to investigate. They are complex in terms of molecular
composition and structure, functional over a wide range of time scales, and characterized by …
composition and structure, functional over a wide range of time scales, and characterized by …
A call for systematic research on solute carriers
A Cesar-Razquin, B Snijder, T Frappier-Brinton… - Cell, 2015 - cell.com
Solute carrier (SLC) membrane transport proteins control essential physiological functions,
including nutrient uptake, ion transport, and waste removal. SLCs interact with several …
including nutrient uptake, ion transport, and waste removal. SLCs interact with several …
Structures and mechanism of the plant PIN-FORMED auxin transporter
KL Ung, M Winkler, L Schulz, M Kolb, DP Janacek… - Nature, 2022 - nature.com
Auxins are hormones that have central roles and control nearly all aspects of growth and
development in plants,–. The proteins in the PIN-FORMED (PIN) family (also known as the …
development in plants,–. The proteins in the PIN-FORMED (PIN) family (also known as the …
Structural insights into auxin recognition and efflux by Arabidopsis PIN1
Z Yang, J Xia, J Hong, C Zhang, H Wei, W Ying, C Sun… - Nature, 2022 - nature.com
Polar auxin transport is unique to plants and coordinates their growth and development,.
The PIN-FORMED (PIN) auxin transporters exhibit highly asymmetrical localizations at the …
The PIN-FORMED (PIN) auxin transporters exhibit highly asymmetrical localizations at the …
[HTML][HTML] Structural insights into the HBV receptor and bile acid transporter NTCP
Around 250 million people are infected with hepatitis B virus (HBV) worldwide, and 15
million may also carry the satellite virus hepatitis D virus (HDV), which confers even greater …
million may also carry the satellite virus hepatitis D virus (HDV), which confers even greater …
Structure of the bile acid transporter and HBV receptor NTCP
J Asami, KT Kimura, Y Fujita-Fujiharu, H Ishida… - Nature, 2022 - nature.com
Chronic infection with hepatitis B virus (HBV) affects more than 290 million people
worldwide, is a major cause of cirrhosis and hepatocellular carcinoma, and results in an …
worldwide, is a major cause of cirrhosis and hepatocellular carcinoma, and results in an …
Sodium taurocholate cotransporting polypeptide is a functional receptor for human hepatitis B and D virus
Human hepatitis B virus (HBV) infection and HBV-related diseases remain a major public
health problem. Individuals coinfected with its satellite hepatitis D virus (HDV) have more …
health problem. Individuals coinfected with its satellite hepatitis D virus (HDV) have more …
Shared molecular mechanisms of membrane transporters
D Drew, O Boudker - Annual review of biochemistry, 2016 - annualreviews.org
The determination of the crystal structures of small-molecule transporters has shed light on
the conformational changes that take place during structural isomerization from outward-to …
the conformational changes that take place during structural isomerization from outward-to …
Structures and mechanisms of the Arabidopsis auxin transporter PIN3
Abstract The PIN-FORMED (PIN) protein family of auxin transporters mediates polar auxin
transport and has crucial roles in plant growth and development,. Here we present cryo …
transport and has crucial roles in plant growth and development,. Here we present cryo …
[HTML][HTML] Intestinal absorption of bile acids in health and disease
AL Ticho, P Malhotra, PK Dudeja, RK Gill… - Comprehensive …, 2019 - ncbi.nlm.nih.gov
The intestinal reclamation of bile acids is crucial for the maintenance of their enterohepatic
circulation. The majority of bile acids are actively absorbed via specific transport proteins …
circulation. The majority of bile acids are actively absorbed via specific transport proteins …