Triple-negative breast cancer: a brief review about epidemiology, risk factors, signaling pathways, treatment and role of artificial intelligence
NM Almansour - Frontiers in Molecular Biosciences, 2022 - frontiersin.org
Triple-negative breast cancer (TNBC) is a kind of breast cancer that lacks estrogen,
progesterone, and human epidermal growth factor receptor 2. This cancer is responsible for …
progesterone, and human epidermal growth factor receptor 2. This cancer is responsible for …
Current development of CBP/p300 inhibitors in the last decade
ZX He, BF Wei, X Zhang, YP Gong, LY Ma… - European Journal of …, 2021 - Elsevier
CBP/p300, functioning as histone acetyltransferases and transcriptional co-factors,
represents an attractive target for various diseases, including malignant tumor. The …
represents an attractive target for various diseases, including malignant tumor. The …
[HTML][HTML] Structural basis of SARS-CoV-2 3CLpro and anti-COVID-19 drug discovery from medicinal plants
The recent pandemic of coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 has
raised global health concerns. The viral 3-chymotrypsin-like cysteine protease (3CL pro) …
raised global health concerns. The viral 3-chymotrypsin-like cysteine protease (3CL pro) …
Designing of a next generation multiepitope based vaccine (MEV) against SARS-COV-2: Immunoinformatics and in silico approaches
Coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory
coronavirus 2 (SARS-COV-2) is a significant threat to global health security. Till date, no …
coronavirus 2 (SARS-COV-2) is a significant threat to global health security. Till date, no …
Pharmacoinformatics and molecular dynamics simulation studies reveal potential covalent and FDA-approved inhibitors of SARS-CoV-2 main protease 3CLpro
The SARS-CoV-2 was confirmed to cause the global pandemic of coronavirus disease 2019
(COVID-19). The 3-chymotrypsin-like protease (3CLpro), an essential enzyme for viral …
(COVID-19). The 3-chymotrypsin-like protease (3CLpro), an essential enzyme for viral …
[HTML][HTML] Plant-derived secondary metabolites as the main source of efflux pump inhibitors and methods for identification
The upsurge of multiple drug resistance (MDR) bacteria substantially diminishes the
effectiveness of antibiotic arsenal and therefore intensifies the rate of therapeutic failure. The …
effectiveness of antibiotic arsenal and therefore intensifies the rate of therapeutic failure. The …
Structure-based pharmacophore modeling, virtual screening, molecular docking, ADMET, and molecular dynamics (MD) simulation of potential inhibitors of PD-L1 …
L Luo, A Zhong, Q Wang, T Zheng - Marine Drugs, 2021 - mdpi.com
Background: In the past decade, several antibodies directed against the PD-1/PD-L1
interaction have been approved. However, therapeutic antibodies also exhibit some …
interaction have been approved. However, therapeutic antibodies also exhibit some …
Multiepitope-based subunit vaccine design and evaluation against respiratory syncytial virus using reverse vaccinology approach
Respiratory syncytial virus (RSV) is primarily associated with respiratory disorders globally.
Despite the availability of information, there is still no competitive vaccine available for RSV …
Despite the availability of information, there is still no competitive vaccine available for RSV …
Recent advances on small-molecule bromodomain-containing histone acetyltransferase inhibitors
M Liu, K Zhang, Q Li, H Pang, Z Pan… - Journal of Medicinal …, 2023 - ACS Publications
In recent years, substantial research has been conducted on molecular mechanisms and
inhibitors targeting bromodomains (BRDs) and extra-terminal (BET) family proteins. On this …
inhibitors targeting bromodomains (BRDs) and extra-terminal (BET) family proteins. On this …
[HTML][HTML] Discovery of human coronaviruses pan-papain-like protease inhibitors using computational approaches
The papain-like protease (PL pro) is vital for the replication of coronaviruses (CoVs), as well
as for escaping innate-immune responses of the host. Hence, it has emerged as an …
as for escaping innate-immune responses of the host. Hence, it has emerged as an …