DNA replication must be precisely controlled in order to maintain genome stability.
Transition through cell cycle phases is regulated by a family of Cyclin-Dependent Kinases …

Efficient S phase entry is essential for development, tissue repair, and immune defences.
However, hyperactive or expedited S phase entry causes replication stress, DNA damage …

Purpose: Cyclin-dependent kinase (CDK) 4/6 drives cell proliferation in estrogen receptor–
positive (ER+) breast cancer. This single-arm phase II neoadjuvant trial (NeoPalAna) …

Uncontrolled cell proliferation is the hallmark of cancer, and tumor cells have typically
acquired damage to genes that directly regulate their cell cycles. Genetic alterations …

Much has been written about the functions of the E2F transcription factor and the product of
the retinoblastoma tumor suppressor gene (pRB). These proteins have been described in …

Cells decide to proliferate or remain quiescent using signaling pathways that link information
about the cellular environment to the G1 phase of the cell cycle. Progression through G1 …

Cyclin-dependent kinases (cdks) are critical regulators of cell cycle progression and RNA
transcription. A variety of genetic and epigenetic events cause universal overactivity of the …

▪ Abstract The eucaryotic cell cycle is regulated by the periodic synthesis and destruction of
cyclins that associate with and activate cyclin-dependent kinases. Cyclin-dependent kinase …

We present evidence that phosphorylation of the C-terminal region of Rb by Cdk4/6 initiates
successive intramolecular interactions between the C-terminal region and the central …

The retinoblastoma protein (pRb) acts to constrain the G1-S transition in mammalian cells.
Phosphorylation of pRb in G1 inactivates its growth-inhibitory function, allowing for cell cycle …