Abstract PROteolysis TArgeting Chimeras (PROTACs) technology is a new protein-
degradation strategy that has emerged in recent years. It uses bifunctional small molecules …

Natural products are an important source of new drugs for the treatment of various diseases.
However, developing natural product-based new medicines through random moiety …

Covering: upto 2022 Natural products have an embedded recognition of protein surfaces.
They possess this property as they are produced by biosynthetic enzymes and are …

Targeted protein degradation (TPD), a promising therapeutic strategy in drug discovery, has
great potential to regulate the endogenous degradation of undruggable targets with small …

In recent years, biologically active natural products have gradually become important agents
in the field of drug research and development because of their wide availability and variety …

Soil salinization limits hull-less barley cultivation in the Qinghai-Tibet Plateau of China.
However, some wild hull-less barley seeds accumulate high melatonin (MEL) during …

Small molecules can serve as leads for new therapeutics as well as powerful tools to
investigate biological processes. Understanding the interactions of these molecules …

Targeted protein degradation (TPD) has emerged as a powerful approach for eliminating
cancer-causing proteins through an “event-driven” pharmacological mode. Proteolysis …

Dehydrocurvularin is a potent antineoplastic agent irreversibly blocking ATP-citrate lyase:
evidence from chemoproteomics - Chemical Communications (RSC Publishing) DOI:10.1039/C9CC00256A …

Abstract Background Pseudolaric acid B (PAB), a diterpene acid isolated from the root bark
of Pseudolarix kaempferi, exhibits a potent anti-cancer activity in a variety of tumor cells …