HOXA9 deregulation underlies a large subset of aggressive acute leukemias.
Understanding the mechanisms regulating the expression and activity of HOXA9, along with …

The differentiation from multipotent hematopoietic stem cells (HSC) to mature and functional
blood cells requires the finely tuned regulation of gene expression at each stage of …

The outcome of treatment-refractory and/or relapsed pediatric T cell acute lymphoblastic
leukemia (T-ALL) is extremely poor, and the genetic basis for this is not well understood …

Using next-generation sequencing of primary acute myeloid leukemia (AML) specimens, we
identified to our knowledge the first unifying genetic network common to the two subgroups …

Nucleophosmin (NPM1) is among the most frequently mutated genes in acute myeloid
leukemia (AML). It is not known, however, how the resulting oncoprotein mutant NPM1 is …

The transformed state in acute leukemia requires gene regulatory programs involving
transcription factors and chromatin modulators. Here, we uncover an IRF8-MEF2D …

The transcription factor Meis1 drives myeloid leukemogenesis in the context of Hox gene
overexpression but is currently considered undruggable. We therefore investigated whether …

The genomes of myeloid malignancies are characterized by epigenomic abnormalities.
Heterozygous, inactivating ten-eleven translocation 2 (TET2) mutations and neomorphic …

Although originally described as transcriptional activator, SPI1/PU. 1, a major player in
haematopoiesis whose alterations are associated with haematological malignancies, has …

Altered transcription is a cardinal feature of acute myeloid leukemia (AML); however, exactly
how mutations synergize to remodel the epigenetic landscape and rewire three-dimensional …