Whether and how human tumours are genetically unstable has been debated for decades.
There is now evidence that most cancers may indeed be genetically unstable, but that the …

Colorectal cancer arises as a consequence of the accumulation of genetic alterations (gene
mutations, gene amplification, and so on) and epigenetic alterations (aberrant DNA …

Many human tumours show centrosome aberrations, indicating an underlying deregulation
of centrosome structure, duplication or segregation. Centrosomes organize microtubule …

Aberrations in centrosome numbers have long been implicated in aneuploidy and
tumorigenesis, but their origins are unknown. Here we have examined how overexpression …

Microtubules are highly dynamic cellular polymers made of αβ-tubulin and associated
proteins. They play a key role during mitosis, participating in the exact organization and …

Colorectal cancer affected∼ 135,000 people in the United States in 2001, resulting in
57,000 deaths. At the cellular level, colorectal cancer results from the progressive …

Checkpoints of DNA integrity are conserved throughout evolution, as are the kinases ATM
(Ataxia Telangiectasia mutated) and ATR (Ataxia-and Rad-related), which are related to …

Eukaryotic cells respond to DNA damage by arresting the cell cycle and modulating gene
expression to ensure efficient DNA repair. The human ATR kinase and its homolog in yeast …

It has long been known that rearrangements of chromosomes through breakage-fusion-
bridge (BFB) cycles may cause variability of phenotypic and genetic traits within a cell …

Centrosomes play critical roles in processes that ensure proper segregation of
chromosomes and maintain the genetic stability of human cells. They contribute to mitotic …