Heart failure is a pressing worldwide public-health problem with millions of patients having
worsening heart failure. Despite all the available therapies, the condition carries a very poor …

Age is the most important risk factor for most diseases. Mitochondria play a central role in
bioenergetics and metabolism. In addition, several lines of evidence indicate the impact of …

Ferroptosis is a programmed iron-dependent cell death associated with peroxidation of
lipids particularly, phospholipids. Several studies suggested a possible contribution of …

Regulated necrosis has been reported to exert an important role in the pathogenesis of
various diseases, including renal ischemia-reperfusion (I/R) injury. Damage to renal tubular …

Ischemic heart disease is a leading cause of death worldwide. Primarily, ischemia causes
decreased oxygen supply, resulting in damage of the cardiac tissue. Naturally …

Significance: Mitochondria represent a major source of intracellular reactive oxygen species
(ROS) generation. This is often a consequence of oxidative phosphorylation, which can …

Excessive production of mitochondrial reactive oxygen species (mROS) is strongly
associated with mitochondrial and cellular oxidative damage, aging, and degenerative …

Mitochondrial dysfunction characterized by impaired bioenergetics, oxidative stress and
aldehydic load is a hallmark of heart failure. Recently, different research groups have …

The cardiac benefits of exercise have been recognized for centuries. Studies have
undisputedly shown that regular exercise is beneficial for the cardiovascular system in …

Discovering compounds and mechanisms for inhibiting ferroptosis, a form of regulated,
nonapoptotic cell death, has been of great interest in recent years. In this study, we …