The prevalence of obesity has rapidly escalated and now represents a major public health
concern. Although genetic associations with obesity and related metabolic disorders such as …

Understanding of the role of insulin in the brain has gradually expanded, from initial
conceptions of the brain as insulin-insensitive through identification of a role in regulation of …

Defects in insulin production and signaling are suspected to share a key role in diabetes
and Alzheimer disease (AD), two age-related pathologies. In this study, we investigated the …

J. Neurochem.(2010) 114, 1581–1589. Abstract Long term consumption of a high fat diet
(HFD) contributes to increased morbidity and mortality. Yet the specific effects of HFD …

Diabetes may adversely affect cognitive function, but the underlying mechanisms are
unknown. To investigate whether manipulations that enhance neurotrophin levels will also …

Diabetes mellitus is the most common metabolic disease, and its prevalence is increasing. A
growing body of evidence, both in animal models and epidemiological studies, has …

The incidence of obesity is increasing worldwide, and is especially pronounced in
developed western countries. While the consequences of obesity on metabolic and …

Diabetes-related cognitive dysfunction is a consequence of changes within the central
nervous system that are secondary to chronic hyperglycemia, oxidative stress, and …

Clinical studies suggest that obesity and Type 2 (insulin-resistant) diabetes impair the
structural integrity of medial temporal lobe regions involved in memory and confer greater …

The incidence of diabetes has more than doubled in the United States in the last 30 years
and the global disease rate is projected to double by 2030. Cognitive impairment has been …