Nrf2/Keap1/ARE signaling: Towards specific regulation
The Nrf2 transcription factor governs the expression of hundreds genes involved in cell
defense against oxidative stress, the hallmark of numerous diseases such as …
defense against oxidative stress, the hallmark of numerous diseases such as …
NRF2 and the Hallmarks of Cancer
The transcription factor NRF2 is the master regulator of the cellular antioxidant response.
Though recognized originally as a target of chemopreventive compounds that help prevent …
Though recognized originally as a target of chemopreventive compounds that help prevent …
NRF2 controls iron homeostasis and ferroptosis through HERC2 and VAMP8
Enhancing the intracellular labile iron pool (LIP) represents a powerful, yet untapped
strategy for driving ferroptotic death of cancer cells. Here, we show that NRF2 maintains iron …
strategy for driving ferroptotic death of cancer cells. Here, we show that NRF2 maintains iron …
Redox regulation by NRF2 in aging and disease
NRF2, a transcription factor that has been deemed the master regulator of cellular redox
homeostasis, declines with age. NRF2 transcriptionally upregulates genes that combat …
homeostasis, declines with age. NRF2 transcriptionally upregulates genes that combat …
Nrf2 at the heart of oxidative stress and cardiac protection
QM Chen, AJ Maltagliati - Physiological genomics, 2018 - journals.physiology.org
The NFE2L2 gene encodes the transcription factor Nrf2 best known for regulating the
expression of antioxidant and detoxification genes. Gene knockout approaches have …
expression of antioxidant and detoxification genes. Gene knockout approaches have …
Canonical and non-canonical mechanisms of Nrf2 activation
CA Silva-Islas, PD Maldonado - Pharmacological research, 2018 - Elsevier
Abstract Nuclear Factor Erythroid 2-related factor 2 (Nrf2) is a transcription factor that
regulates the expression of genes involved in the metabolism, immune response, cellular …
regulates the expression of genes involved in the metabolism, immune response, cellular …
Novel target for treating Alzheimer's Diseases: Crosstalk between the Nrf2 pathway and autophagy
W Zhang, C Feng, H Jiang - Ageing research reviews, 2021 - Elsevier
Abstract In mammals, the Keap1-Nrf2-ARE pathway (henceforth,“the Nrf2 pathway”) and
autophagy are major intracellular defence systems that combat oxidative damage and …
autophagy are major intracellular defence systems that combat oxidative damage and …
Recent progress on targeting ferroptosis for cancer therapy
G Xu, H Wang, X Li, R Huang, L Luo - Biochemical Pharmacology, 2021 - Elsevier
Ferroptosis is a new mode of cell death different from cell necrosis, autophagy, apoptosis,
and pyroptosis, which depends on the accumulation of reactive oxygen species (ROS) …
and pyroptosis, which depends on the accumulation of reactive oxygen species (ROS) …
Oxidative stress and chronic inflammation in osteoarthritis: can NRF2 counteract these partners in crime?
AS Marchev, PA Dimitrova, AJ Burns… - Annals of the New …, 2017 - Wiley Online Library
Osteoarthritis (OA) is an age‐related joint degenerative disease associated with pain, joint
deformity, and disability. The disease starts with cartilage damage but then progressively …
deformity, and disability. The disease starts with cartilage damage but then progressively …
The intricacies of NRF2 regulation in cancer
The complex role of NRF2 in the context of cancer continues to evolve. As a transcription
factor, NRF2 regulates various genes involved in redox homeostasis, protein degradation …
factor, NRF2 regulates various genes involved in redox homeostasis, protein degradation …