Small molecular mimetics of antimicrobial peptides as a promising therapy to combat bacterial resistance

P Teng, H Shao, B Huang, J Xie, S Cui… - Journal of Medicinal …, 2023 - ACS Publications
Clinically, antibiotics are widely used to treat infectious diseases; however, excessive drug
abuse and overuse exacerbate the prevalence of drug-resistant bacterial pathogens …

[HTML][HTML] Antimicrobial materials for endotracheal tubes: A review on the last two decades of technological progress

D Alves, T Grainha, MO Pereira, SP Lopes - Acta Biomaterialia, 2023 - Elsevier
Ventilator-associated pneumonia (VAP) is an unresolved problem in nosocomial settings,
remaining consistently associated with a lack of treatment, high mortality, and prolonged …

From marine metabolites to the drugs of the future: Squalamine, trodusquemine, their steroid and triterpene analogues

O Kazakova, G Giniyatullina, D Babkov… - International journal of …, 2022 - mdpi.com
This review comprehensively describes the recent advances in the synthesis and
pharmacological evaluation of steroid polyamines squalamine, trodusquemine, ceragenins …

Antimicrobial Solutions for Endotracheal Tubes in Prevention of Ventilator-Associated Pneumonia

L Marcut, V Manescu, A Antoniac, G Paltanea, A Robu… - Materials, 2023 - mdpi.com
Ventilator-associated pneumonia is one of the most frequently encountered hospital
infections and is an essential issue in the healthcare field. It is usually linked to a high …

Ceragenins exhibit antiviral activity against SARS-CoV-2 by increasing the expression and release of type I interferons upon activation of the host's immune response

Ł Suprewicz, A Szczepański, M Lenart, E Piktel… - Antiviral Research, 2023 - Elsevier
The COVID-19 pandemic caused by Severe Acute Respiratory Syndrome Coronavirus 2
(SARS-CoV-2) heavily burdened the entire world socially and economically. Despite a …

Antibacterial Plasma Polymer Coatings on 3D Materials for Orthopedic Applications

A Dao, C Gaitanos, S Kamble… - Advanced Materials …, 2024 - Wiley Online Library
Covalent biofunctionalization of implant surfaces using anti microbial agents is a promising
approach to reducing bone infection and implant failure. Radical‐rich, ion‐assisted plasma …

Recent progress in bile acid-based antimicrobials

C Lin, Y Wang, M Le, KF Chen, YG Jia - Bioconjugate Chemistry, 2021 - ACS Publications
With the emergence of drug-resistant bacteria and the formation of biofilms by bacteria and
fungi, microbial infections gradually threaten global health. Natural antimicrobial peptides …

Bactericidal activity of ceragenin in combination with ceftazidime, levofloxacin, co-trimoxazole, and colistin against the opportunistic pathogen Stenotrophomonas …

P Paprocka, A Mańkowska, K Skłodowski, G Król… - Pathogens, 2022 - mdpi.com
Background: Stenotrophomonas maltophilia (S. maltophilia) is an emerging opportunistic
Gram-negative rod causing nosocomial infections predominantly in immunocompromised …

Antimicrobial Activity of Ceragenins against Vancomycin-Susceptible and -Resistant Enterococcus spp.

M Hacioglu, FN Yilmaz, O Oyardi, C Bozkurt Guzel… - Pharmaceuticals, 2023 - mdpi.com
Ceragenins (CSAs) are a new class of antimicrobial agents designed to mimic the activities
of endogenous antimicrobial peptides. In this study, the antibacterial activities of various …

In vitro assessment of CSA-131 and CSA-131 poloxamer form for the treatment of Stenotrophomonas maltophilia infections in cystic fibrosis

Ö Oyardi, PB Savage, Z Erturan… - Journal of …, 2021 - academic.oup.com
Background Stenotrophomonas maltophilia is a Gram-negative bacterium resistant to
several antibiotics and its prevalence in cystic fibrosis (CF) patients is increasing. Objectives …