LPS binding protein (LBP) and CD14 play key roles in promoting innate immunity to Gram-
negative bacteria by transferring LPS to the signaling receptor complex, MD-2/Toll-like …

The glycosyl-phosphatidylinositol-linked glycoprotein CD14 is expressed in myeloid cells
and serum. It binds Gram-negative and-positive bacterial cell wall components and …

It has become apparent that astrocytes may be important contributors to inflammatory
immune responses within the brain in response to microbial challenges. To date, the …

CD14, a myeloid cell-surface receptor and soluble plasma protein, binds LPS and other
microbial molecules and initiates the innate immune response to bacterial invasion. The …

Lipopolysaccharide (endotoxin, LPS) is a major recognition marker for the detection of gram‐
negative bacteria by the host and a powerful initiator of the inflammatory response to …

The immune response in the central nervous system (CNS) is under tight control of
regulatory mechanisms, resulting in the establishment of immune privilege. CNS injury …

Microglia manage immunosurveillance and mediate inflammation, both suggested to be
important in Alzheimer's disease (AD). The aim of this study was to investigate if microglial …

Gamma interferon (IFN-γ) is an important mediator of endotoxin (lipopolysaccharide [LPS])-
induced immune responses. However, the specific cell types that produce IFN-γ in response …

Animals that cannot sense endotoxin may die if they are infected by Gram-negative bacteria.
Animals that sense endotoxin and respond too vigorously may also die, victims of their own …

CD14 is a receptor for cell wall components of Gram-negative and Gram-positive bacteria
that has been implicated in the initiation of the inflammatory response to sepsis. To …