Postsynaptic nAChRs in the peripheral nervous system are critical for neuromuscular and
autonomic neurotransmission. Pre-and peri-synaptic nAChRs in the brain modulate …

Within the superfamily of pentameric ligand-gated ion channels, cholinergic nicotinic
receptors (nAChRs) were classically identified to mediate synaptic transmission in the …

Nicotinic acetylcholine receptors (nAChRs) are master regulators of immune functions via
the cholinergic anti-inflammatory pathway and are expressed in microglia, the brain's …

Abstract α-Conotoxins are disulfide-rich and well-structured peptides, most of which can
block nicotinic acetylcholine receptors (nAChRs) with exquisite selectivity and potency …

Recently, we discovered a cholinergic mechanism that inhibits the adenosine triphosphate
(ATP)-dependent release of interleukin-1β (IL-1β) by human monocytes via nicotinic …

Blood levels of the acute phase reactant C-reactive protein (CRP) are frequently measured
as a clinical marker for inflammation, but the biological functions of CRP are still …

Transcripts for α9 and α10 nicotinic acetylcholine receptor (nAChR) subunits are found in
diverse tissues. The function of α9α10 nAChRs is best known in mechanosensory cochlear …

Neuronal nicotinic acetylcholine receptors containing the α9 or the α9 and α10 subunits are
expressed in various extra-neuronal tissues. Moreover, most cancer cells and tissues highly …

Activation of nicotinic acetylcholine receptors (nAChRs) expressed by innate immune cells
can attenuate pro-inflammatory responses. Silent nAChR agonists, which down-modulate …

Abstract The α9-and α7-containing nicotinic acetylcholine receptors (nAChRs) mediate
numerous physiological and pathological processes by complex mechanisms that are …