The AMP-activated protein kinase (AMPK) system acts as a sensor of cellular energy status
that is conserved in all eukaryotic cells. It is activated by increases in the cellular AMP: ATP …

5-Aminoimidazole-4-carboxamide ribonucleoside (AICAr) has been one of the most
commonly used pharmacological modulators of AMPK activity. The majority of early studies …

Targeting cancer cell metabolism is a new promising strategy to fight cancer. Metformin, a
widely used antidiabetic agent, exerts antitumoral and antiproliferative action. In this study …

Chronic lymphocytic leukaemia is the commonest form of leukaemia in Europe and North
America, and mainly, though not exclusively, affects older individuals. It has a very variable …

The AMP-activated protein kinase (AMPK) system is a regulator of energy balance at both
the cellular and whole-body levels that, once activated by low energy status, effects a switch …

Vascular smooth muscle cell (VSMC) proliferation is a critical event in the development and
progression of vascular diseases, including atherosclerosis. We investigated whether the …

Despite the advances in biomedical research and clinical applications, cancer remains a
leading cause of death worldwide. Given the limitations of conventional chemotherapeutics …

Zearalenone (ZEA) can perturb the differentiation of cells, reduce the generation of
reproductive cells and induce a death of germ cells, but the molecular mechanism remains …

The role of autophagy in cisplatin anticancer action was investigated using human U251
glioma, rat C6 glioma and mouse L929 fibrosarcoma cell lines. A dose‐and time‐dependent …

5-Fluorouracil (5-FU) is one of the widely used chemotherapeutic drugs targeting various
cancers, but its chemo-resistance remains as a major obstacle in clinical settings. In the …