Eukaryotic genomes contain a variety of structured patterns: repetitive elements, binding
sites of DNA and RNA associated proteins, splice sites, and so on. Often, these structured …

Background & Aims N 6-Methyladenosine (m 6 A) is the most prevalent RNA modification
and recognized as an important epitranscriptomic mechanism in colorectal cancer (CRC) …

Chimeric antigen receptor (CAR)-T cell-based immunotherapy for cancer and
immunological diseases has made great strides, but it still faces multiple hurdles. Finding …

Extensive epidemiological studies suggest that the diabetic population is at higher risk of
site-specific cancers. The diabetes–cancer link has been hypothesized to rely on various …

CD8 T cells play essential roles in anti-tumor immune responses. Here, we performed
genome-scale CRISPR screens in CD8 T cells directly under cancer immunotherapy …

TGF-β signaling can be pro-tumorigenic or tumor suppressive. We investigated this duality in
pancreatic ductal adenocarcinoma (PDA), which, with other gastrointestinal cancers …

Identifying master regulators of biological processes and mapping their downstream gene
networks are key challenges in systems biology. We developed a computational method …

CD8+ T cells control tumors but inevitably become dysfunctional in the tumor
microenvironment. Here, we show that sodium chloride (NaCl) counteracts T cell dysfunction …

According to current models, once the cell has reached terminal differentiation, the enhancer
repertoire is completely established and maintained by cooperatively acting lineage-specific …

Fatty acid uptake and altered metabolism constitute hallmarks of metastasis,, yet evidence of
the underlying biology, as well as whether all dietary fatty acids are prometastatic, is lacking …