Molecular docking in the pharmaceutical industry is a powerful in silico approach for
discovering novel therapies for unmet medical needs predicting drug–target interactions. It …

The sequential synthesis of N-heterocycles from saturated ketones poses significant
challenges and has rarely been reported. Herein, an efficient synthesis of alkenylated …

Chalcones belong to the flavonoids family and are natural compounds which show
promising larvicidal property against Aedes aegypti larvae. Aiming to obtain a synthetic …

Two new isostructural halogenated dihydroquinolinones were synthesized and
characterized by single crystal X-ray diffraction. A detailed isostructural analysis of the …

In this paper, we performed an in silico-driven design model to synthesize compounds with
biological activity. This rational design has the advantage of decreasing the time and the …

Diclofenac diethylammonium belongs to the class of non-steroidal anti-inflammatory drugs,
and it is widely used to relieve pain and reduce systemic inflammation. This drug exists in …

The crystals of new ligand, namely (3 E)-6-methyl-3-{1-[(pyridin-3-ylmethyl) amino] ethylene}-
2 H-pyran-2, 4 (3 H)-dione)(LAT1), were synthesized using the evaporation solution …

Abstract Compounds with dihydroquinoline-4 (1H)-one nuclei have been reported in the
literature for being important in the development of medicines due to their broad spectrum of …

The process of search of a lead molecule is long and tiresome process. Luckily,
computational tools have come to the emancipation and have doubtlessly played a crucial …

A demanda por novos agentes agroquímicos gera uma busca, cada vez maior, pelo
desenvolvimento ou aperfeiçoamento de moléculas que possibilitem uma redução no …