Ciliopathies are inherited human disorders caused by both motile and non‐motile cilia
dysfunction that form an important and rapidly expanding disease category. Ciliopathies are …

In 1892, JL Wolff proposed that bone could respond to mechanical and biophysical stimuli
as a dynamic organ. This theory presents a unique opportunity for investigations on bone …

Osteoclasts and osteoblasts play a major role in bone tissue homeostasis. The homeostasis
and integrity of bone tissue are maintained by ensuring a balance between osteoclastic and …

Intraflagellar transport proteins (IFT) are required for hedgehog (Hh) signalling transduction
that is essential for bone development, however, how IFT proteins regulate Hh signalling in …

Cells need to sense their mechanical environment during the growth of developing tissues
and maintenance of adult tissues. The concept of force-sensing mechanisms that act …

Ciliopathy encompasses a diverse group of autosomal recessive genetic disorders caused
by mutations in genes coding for components of the primary cilia. Skeletal ciliopathy forms a …

The primary cilium is a cellular organelle that coordinates signaling pathways critical for cell
proliferation, differentiation, survival, and homeostasis. Intraflagellar transport (IFT) plays a …

Abstract Purpose of Review Osteocytes comprise> 95% of the cellular component in bone
tissue and produce a wide range of cytokines and cellular signaling molecules in response …

Diabetes-associated bone complications lead to fragile bone mechanical strength and
osteoporosis, aggravating the disease burden of patients. Advanced evidence shows that …

Degenerative disc disease (DDD) is associated with intervertebral disc degeneration of
spinal instability. Here, we report that the cilia of nucleus pulposus (NP) cells mediate …