Mitochondrial complex I is the primary entry point for electrons into the electron transport
chain, required for the bulk of cellular ATP production via oxidative phosphorylation …

Transcription activator‐like effector (TALE) nucleases (TALENs) have recently emerged as a
revolutionary genome editing tool in many different organisms and cell types. The site …

Complex I (NADH: ubiquinone oxidoreductase) is the first enzyme of the mitochondrial
respiratory chain and is composed of 45 subunits in humans, making it one of the largest …

Mammalian respiratory complex I (CI) is a 45-subunit, redox-driven proton pump that
generates an electrochemical gradient across the mitochondrial inner membrane to power …

The haploinsufficiency of C9orf72 is implicated in the most common forms of amyotrophic
lateral sclerosis (ALS) and frontotemporal dementia (FTD), but the full spectrum of C9orf72 …

Cytosolic dynamin-related protein 1 (Drp1, also known as DNM1L) is required for both
mitochondrial and peroxisomal fission. Drp1-dependent division of these organelles is …

Abstract Dynamin-related protein 1 (Drp1) is essential for mitochondrial and peroxisomal
fission. Recent studies propose that Drp1 does not sever but rather constricts mitochondrial …

Key points A classic unresolved issue in human integrative physiology involves the role of
exercise intensity, duration and volume in regulating skeletal muscle adaptations to training …

Mitochondrial dysfunction is a key feature in both aging and neurodegenerative diseases
including Alzheimer's disease (AD), but the molecular signature that distinguishes …

Coenzyme Q (ubiquinone or CoQ) is an essential lipid that plays a role in mitochondrial
respiratory electron transport and serves as an important antioxidant. In human and yeast …