Neuromyelitis optica spectrum disorders: from pathophysiology to therapeutic strategies

E Carnero Contentti, J Correale - Journal of neuroinflammation, 2021 - Springer
Neuromyelitis optica (NMO) is a chronic inflammatory autoimmune disease of the central
nervous system (CNS) characterized by acute optic neuritis (ON) and transverse myelitis …

Update on the diagnosis and treatment of neuromyelits optica spectrum disorders (NMOSD)–revised recommendations of the Neuromyelitis Optica Study Group …

S Jarius, O Aktas, I Ayzenberg, J Bellmann-Strobl… - Journal of …, 2023 - Springer
The term 'neuromyelitis optica spectrum disorders'(NMOSD) is used as an umbrella term that
refers to aquaporin-4 immunoglobulin G (AQP4-IgG)-positive neuromyelitis optica (NMO) …

Diagnosis and treatment of NMO spectrum disorder and MOG-encephalomyelitis

N Borisow, M Mori, S Kuwabara, M Scheel… - Frontiers in …, 2018 - frontiersin.org
Neuromyelitis optica spectrum disorders (NMOSD) are autoantibody mediated chronic
inflammatory diseases. Serum antibodies (Abs) against the aquaporin-4 water channel lead …

Outcome prediction models in AQP4-IgG positive neuromyelitis optica spectrum disorders

J Palace, DY Lin, D Zeng, M Majed, L Elsone, S Hamid… - Brain, 2019 - academic.oup.com
Pathogenic antibodies targeting the aquaporin-4 water channel on astrocytes are
associated with relapsing inflammatory neuromyelitis optica spectrum disorders. The clinical …

Rituximab abrogates aquaporin-4–specific germinal center activity in patients with neuromyelitis optica spectrum disorders

V Damato, J Theorell, A Al-Diwani… - Proceedings of the …, 2022 - National Acad Sciences
Neuromyelitis optica spectrum disorders (NMOSDs) are caused by immunoglobulin G (IgG)
autoantibodies directed against the water channel aquaporin-4 (AQP4). In NMOSDs …

Update on the diagnosis and treatment of neuromyelitis optica spectrum disorders (NMOSD)–revised recommendations of the Neuromyelitis Optica Study Group …

T Kümpfel, K Giglhuber, O Aktas, I Ayzenberg… - Journal of …, 2024 - Springer
This manuscript presents practical recommendations for managing acute attacks and
implementing preventive immunotherapies for neuromyelitis optica spectrum disorders …

Neuromyelitis optica

S Jarius, F Paul, BG Weinshenker, M Levy… - Nature Reviews …, 2020 - nature.com
Neuromyelitis optica (NMO; also known as Devic syndrome) is a clinical syndrome
characterized by attacks of acute optic neuritis and transverse myelitis. In most patients …

The B cell immunobiology that underlies CNS autoantibody-mediated diseases

B Sun, M Ramberger, KC O'Connor… - Nature Reviews …, 2020 - nature.com
A rapidly expanding and clinically distinct group of CNS diseases are caused by pathogenic
autoantibodies that target neuroglial surface proteins. Despite immunotherapy, patients with …

Vitamin D in the prevention, prediction and treatment of neurodegenerative and neuroinflammatory diseases

P Koduah, F Paul, JM Dörr - Epma Journal, 2017 - Springer
Vitamin D research has gained increased attention in recent times due to its roles beyond
bone health and calcium homeostasis, such as immunomodulation. In some parts of the …

Latin American consensus recommendations for management and treatment of neuromyelitis optica spectrum disorders in clinical practice

EC Contentti, JI Rojas, E Cristiano, VD Marques… - Multiple sclerosis and …, 2020 - Elsevier
Background During the last two decades, neuromyelitis optica spectrum disorder (NMOSD)
has undergone important changes, with new diagnostic markers and criteria, better …