Background Copper ions are essential for cellular physiology. Cuproptosis is a novel
method of copper-dependent cell death, and the cuproptosis-based signature for glioma …

Context.—The diagnosis and clinical management of patients with diffuse gliomas (DGs)
have evolved rapidly over the past decade with the emergence of molecular biomarkers that …

Evasion of growth suppression is among the prominent hallmarks of cancer. Phosphatase
and tensin homolog (PTEN) and p53 tumor-suppressive pathways are compromised in most …

The cytogenetic and molecular assessment of deletions, amplifications and rearrangements
are key aspects in the diagnosis and therapy of cancer. Not only the initial evaluation and …

The exploration of multifunctional nanomedicine has prompted interest in improving
glioblastoma (GBM) prognosis. In this study, we constructed tumor microenvironment (TME) …

Gliosarcoma is an aggressive brain tumor with histologic features of glioblastoma (GBM)
and soft tissue sarcoma. Despite its poor prognosis, its rarity has precluded analysis of its …

Glioma is one of the most common types of human brain tumor, with high mortality in high‐
grade gliomas (HGG). Low‐grade gliomas (LGG) can progress into HGG, leading to poor …

OBJECTIVE The authors aimed to assess the frequency of homozygous CDKN2A deletion
in isocitrate dehydrogenase (IDH)–mutant diffuse astrocytomas (grade 2/3) and to narrow …

Abstract Background p16, p53, and proliferating cell nuclear antigen (pcna) genes play
significant roles in many chromatin modifications and have been found to be highly …

Adult low-grade gliomas are a rare and aggressive pathology of the central nervous system.
Some of their characteristics contribute to the patient's life expectancy and to their …