Tumor necrosis factor alpha (TNF-α) was initially recognized as a factor that causes the
necrosis of tumors, but it has been recently identified to have additional important functions …

Low back pain (LBP), a prevalent and costly disease around the world, is predominantly
caused by intervertebral disc (IVD) degeneration (IDD). LBP also presents a substantial …

Apoptosis, also named programmed cell death, is a fundament process required for
morphogenetic homeostasis during early development and in pathophysiological …

Autophagy and apoptosis are two important cellular processes with complex and
intersecting protein networks; as such, they have been the subjects of intense investigation …

Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is known for
specifically killing cancer cells, whereas in resistant cancers, TRAIL/TRAIL-R can promote …

The bidirectional causality between kidney injury and inflammation remains an area of
unexpected discoveries. The last decade unraveled the molecular mechanisms of sterile …

Lidocaine is an amide-class local anesthetic used clinically to inhibit pain sensations.
Systemic administration of lidocaine has antinociceptive, antiarrhythmic, anti-inflammatory …

RIPK1 is a death-domain (DD) containing kinase involved in regulating apoptosis,
necroptosis and inflammation. RIPK1 activation is known to be regulated by its DD-mediated …

Cancer is a leading cause of disease burden throughout the world. Many cancers develop
as a result of exposure to both lifestyle and environmental factors that are potentially …

The spread of metastatic cancer cell is the main cause of death worldwide. Cellular and
molecular basis of the action of phytochemicals in the modulation of metastatic cancer …