The question of how genomic information is expressed to determine phenotypes is of central
importance for basic and translational life science research and has been studied by …

The assembly of a eucaryotic ribosome requires the synthesis of four ribosomal ribonucleic
acid (RNA) molecules and more than 75 ribosomal proteins. It utilizes all three RNA …

Background Ribosomes are highly conserved molecular machines whose core composition
has traditionally been regarded as invariant. However, recent studies have reported …

Aneuploidy causes severe developmental defects and is a near universal feature of tumor
cells. Despite its profound effects, the cellular processes affected by aneuploidy are not well …

Using an integrated genomic and proteomic approach, we have investigated the effects of
carbon source perturbation on steady-state gene expression in the yeast Saccharomyces …

In nearly every organism studied, reduced caloric intake extends life span. In yeast, span
extension from dietary restriction is thought to be mediated by the highly conserved, nutrient …

Our previous work has shown that, in the yeast Saccharomyces cerevisiae, any of the eight
stabilizing amino-terminal residues confers a long (> 20 h) half-life on a test protein β …

Background Mutations in genes encoding ribosomal proteins (RPs) have been shown to
cause an array of cellular and developmental defects in a variety of organisms. In …

The transcriptome and proteome change dynamically as cells respond to environmental
stress; however, prior proteomic studies reported poor correlation between mRNA and …

Our previous work has shown that the amino-terminal residue of a short-lived protein is a
distinct component of the protein's degradation signal. To define the complete signal …