The goal of this review is to discuss how behavioral tests in mice relate to the pathological
and neuropsychological features seen in human Alzheimer's disease (AD), and present a …

Epidermal growth factor receptor (EGFR) is the first discovered member of the receptor
tyrosine kinase superfamily and plays a fundamental role during embryogenesis and in …

The generation of amyloid β-peptide (Aβ) by enzymatic cleavages of the β-amyloid
precursor protein (APP) has been at the center of Alzheimer's disease (AD) research. While …

Many lines of evidence support that β-amyloid (Aβ) peptides play an important role in
Alzheimer's disease (AD), the most common cause of dementia. But despite much effort the …

Alzheimer's disease (AD) is a major cause of dementia in the elderly. Pathologically, AD is
characterized by the accumulation of insoluble aggregates of Aβ-peptides that are …

J. Neurochem.(2012) 120 (Suppl. 1), 9–21. Abstract β‐Amyloid precursor protein (APP) is a
critical factor in the pathogenesis of Alzheimer's disease (AD). APP undergoes post …

Mutations in β-amyloid (Aβ) precursor protein (APP) cause familial Alzheimer's disease (AD)
probably by enhancing Aβ peptides production from APP. An antibody targeting Aβ …

Presenilins play essential roles in memory formation, synaptic function, and neuronal
survival. Mutations in the Presenilin-1 (PSEN1) gene are the major cause of familial …

The aberrant accumulation of aggregated β-amyloid peptides (Aβ) as plaques is a hallmark
of Alzheimer's disease (AD) neuropathology and reduction of Aβ has become a leading …

Gene expression changes in the brain affect cognition during normal and pathological
aging. Progress in understanding the cellular processes regulating gene expression …