Dysregulated host response to infection, which cause life‐threatening organ dysfunction,
was defined as sepsis. Sepsis can cause acute and long‐term brain dysfunction, namely …

Neurological and immunological signals constitute an extensive regulatory network in our
body that maintains physiology and homeostasis. The cholinergic system plays a significant …

Acetylcholine (ACh) is the classical neurotransmitter in the cholinergic nervous system.
However, ACh is now known to regulate various immune cell functions. In fact, T cells, B …

Male infertility is a complex and polygenic reproductive disease. 10–15% of the males are
affected by idiopathic infertility conditions. Acetylcholine (ACh), a major neurotransmitter has …

Infections and perioperative stress can lead to neuroinflammation, which in turn is linked to
cognitive impairments such as postoperative delirium or postoperative cognitive …

Given the high mortality associated with sepsis, there is an urgent need for a full
understanding of sepsis pathophysiology and finding new therapeutic regimens. Adipose …

Immunosuppression is associated with long-term mortality during sepsis. However, the
underlying mechanism of immunosuppression remains poorly understood. Toll-like receptor …

Dexmedetomidine is an alpha-2 adrenoreceptor agonist with anti-inflammatory and anti-
delirogenic properties. Pathogenesis of postoperative delirium (POD) includes cholinergic …

Immune cells such as T cells and macrophages express α7 nicotinic acetylcholine receptors
(α7 nAChRs), which contribute to the regulation of immune and inflammatory responses …

Sepsis is an amplified systemic immune-inflammatory response produced by a
microorganism, which involves activation of inflammatory cytokine signaling pathways and …