Translational control of mRNAs during gene expression allows cells to promptly and
dynamically adapt to a variety of stimuli, including in neoplasia in response to aberrant …

The mechanistic/mammalian target of rapamycin (mTOR) plays a master role in cell
proliferation and growth in response to insulin, amino acids, energy levels, and oxygen …

The stage at which ribosomes are recruited to messenger RNAs (mRNAs) is an elaborate
and highly regulated phase of protein synthesis. Upon completion of this step, a ribosome is …

Characterizing the interactions that SARS-CoV-2 viral RNAs make with host cell proteins
during infection can improve our understanding of viral RNA functions and the host innate …

Translation is a key step in the regulation of gene expression and one of the most energy-
consuming processes in the cell. In response to various stimuli, multiple signaling pathways …

SARS-CoV-2 is an RNA virus whose success as a pathogen relies on its abilities to
repurpose host RNA-binding proteins (RBPs) and to evade antiviral RBPs. To uncover the …

In this review we explore the regulation of mRNA cap formation and its impact on
mammalian cells. The mRNA cap is a highly methylated modification of the 5′ end of RNA …

Diverse ribonucleoprotein complexes control mRNA processing, translation, and decay.
Transcripts in these complexes localize to specific regions of the cell and can condense into …

Aging is characterized by the accumulation of damage and other deleterious changes,
leading to the loss of functionality and fitness. Age-related changes occur at most levels of …

Deadenylation generally constitutes the first and pivotal step in eukaryotic messenger RNA
decay. Despite its importance in posttranscriptional regulations, the kinetics of …