Cell sources for in vitro human liver cell culture models
K Zeilinger, N Freyer, G Damm… - Experimental …, 2016 - journals.sagepub.com
In vitro liver cell culture models are gaining increasing importance in pharmacological and
toxicological research. The source of cells used is critical for the relevance and the …
toxicological research. The source of cells used is critical for the relevance and the …
Cell therapy for advanced liver diseases: repair or rebuild
Advanced liver disease presents a significant worldwide health and economic burden and
accounts for 3.5% of global mortality. When liver disease progresses to organ failure the …
accounts for 3.5% of global mortality. When liver disease progresses to organ failure the …
[HTML][HTML] Predictive markers guide differentiation to improve graft outcome in clinical translation of hESC-based therapy for Parkinson's disease
Stem cell treatments for neurodegenerative diseases are expected to reach clinical trials
soon. Most of the approaches currently under development involve transplantation of …
soon. Most of the approaches currently under development involve transplantation of …
[HTML][HTML] Generation of hepatobiliary organoids from human induced pluripotent stem cells
F Wu, D Wu, Y Ren, Y Huang, B Feng, N Zhao… - Journal of …, 2019 - Elsevier
Background & Aims Human induced pluripotent stem cell (hiPSC)-derived liver modeling
systems have the potential to overcome the shortage of donors for clinical application and …
systems have the potential to overcome the shortage of donors for clinical application and …
Small molecule-mediated reprogramming of human hepatocytes into bipotent progenitor cells
Background & Aims Currently, much effort is directed towards the development of new cell
sources for clinical therapy using cell fate conversion by small molecules. Direct lineage …
sources for clinical therapy using cell fate conversion by small molecules. Direct lineage …
[HTML][HTML] Laminins in cellular differentiation
Basement membrane laminins (LNs) have been shown to modulate cellular phenotypes and
differentiation both in vitro and during organogenesis in vivo. At least 16 laminin isoforms …
differentiation both in vitro and during organogenesis in vivo. At least 16 laminin isoforms …
Challenges and opportunities in the design of liver-on-chip microdevices
A Ehrlich, D Duche, G Ouedraogo… - Annual review of …, 2019 - annualreviews.org
The liver is the central hub of xenobiotic metabolism and consequently the organ most prone
to cosmetic-and drug-induced toxicity. Failure to detect liver toxicity or to assess compound …
to cosmetic-and drug-induced toxicity. Failure to detect liver toxicity or to assess compound …
[HTML][HTML] 3D human liver tissue from pluripotent stem cells displays stable phenotype in vitro and supports compromised liver function in vivo
H Rashidi, NT Luu, SM Alwahsh, M Ginai… - Archives of …, 2018 - Springer
Liver disease is an escalating global health issue. While liver transplantation is an effective
mode of therapy, patient mortality has increased due to the shortage of donor organs …
mode of therapy, patient mortality has increased due to the shortage of donor organs …
A versatile biosynthetic hydrogel platform for engineering of tissue analogues
For creating functional tissue analogues in tissue engineering, stem cells require very
specific 3D microenvironments to thrive and mature. Demanding (stem) cell types that are …
specific 3D microenvironments to thrive and mature. Demanding (stem) cell types that are …
3D bioprinting of liver spheroids derived from human induced pluripotent stem cells sustain liver function and viability in vitro
E Goulart, LC de Caires-Junior, KA Telles-Silva… - …, 2019 - iopscience.iop.org
The liver is responsible for many metabolic, endocrine and exocrine functions.
Approximately 2 million deaths per year are associated with liver failure. Modern 3D …
Approximately 2 million deaths per year are associated with liver failure. Modern 3D …