Cells in diverse organisms can store the information of previous environmental conditions
for long periods of time. This form of cellular memory adjusts the cell's responses to future …

Identifying the sources of cell-to-cell variability in signaling dynamics is essential to
understand drug response variability and develop effective therapeutics. However, it is …

Metastasis suppression by high-dose, multi-drug targeting is unsuccessful due to network
heterogeneity and compensatory network activation. Here, we show that targeting driver …

Many intracellular signaling pathways are composed of molecular switches, proteins that
transition between two states—on and off. Typically, signaling is initiated when an external …

Background Stomata are tiny pores in plant leaves that regulate gas and water exchange
between the plant and its environment. Abscisic acid and ethylene are two well-known …

Thoughtful use of simplifying assumptions is crucial to make systems biology models
tractable while still representative of the underlying biology. A useful simplification can …

Many biochemical oscillators are driven by the periodic rise and fall of protein
concentrations or activities. A negative feedback loop underlies such oscillations. The …

The spatial architecture of signaling pathways and the interaction with cell size and
morphology are complex, but little understood. With the advances of single cell imaging and …

From the perspective of human mobility, the COVID-19 pandemic constituted a natural
experiment of enormous reach in space and time. Here, we analyse the inherent multiple …

Compartmental models which yield linear ordinary differential equations (ODEs) provide
common tools for pharmacokinetics (PK) analysis, with exact solutions for drug levels or …