Discovery of microbial natural products by activation of silent biosynthetic gene clusters
PJ Rutledge, GL Challis - Nature reviews microbiology, 2015 - nature.com
Microorganisms produce a wealth of structurally diverse specialized metabolites with a
remarkable range of biological activities and a wide variety of applications in medicine and …
remarkable range of biological activities and a wide variety of applications in medicine and …
Biologically active secondary metabolites from the fungi
Many Fungi have a well-developed secondary metabolism. The diversity of fungal species
and the diversification of biosynthetic gene clusters underscores a nearly limitless potential …
and the diversification of biosynthetic gene clusters underscores a nearly limitless potential …
Genome mining as new challenge in natural products discovery
Drug discovery is based on bioactivity screening of natural sources, traditionally represented
by bacteria fungi and plants. Bioactive natural products and their secondary metabolites …
by bacteria fungi and plants. Bioactive natural products and their secondary metabolites …
[HTML][HTML] Enzymes revolutionize the bioproduction of value-added compounds: From enzyme discovery to special applications
Competitive sustainable production in industry demands new and better biocatalysts,
optimized bioprocesses and cost-effective product recovery. Our review sheds light on the …
optimized bioprocesses and cost-effective product recovery. Our review sheds light on the …
Synthetic biology and molecular genetics in non-conventional yeasts: current tools and future advances
Coupling the tools of synthetic biology with traditional molecular genetic techniques can
enable the rapid prototyping and optimization of yeast strains. While the era of yeast …
enable the rapid prototyping and optimization of yeast strains. While the era of yeast …
[HTML][HTML] Developing fungal heterologous expression platforms to explore and improve the production of natural products from fungal biodiversity
X Meng, Y Fang, M Ding, Y Zhang, K Jia, Z Li… - Biotechnology …, 2022 - Elsevier
Natural products from fungi represent an important source of biologically active metabolites
notably for therapeutic agent development. Genome sequencing revealed that the number …
notably for therapeutic agent development. Genome sequencing revealed that the number …
Unlocking the magic in mycelium: Using synthetic biology to optimize filamentous fungi for biomanufacturing and sustainability
Filamentous fungi drive carbon and nutrient cycling across our global ecosystems, through
its interactions with growing and decaying flora and their constituent microbiomes. The …
its interactions with growing and decaying flora and their constituent microbiomes. The …
Microbial chassis engineering drives heterologous production of complex secondary metabolites
The cryptic secondary metabolite biosynthetic gene clusters (BGCs) far outnumber currently
known secondary metabolites. Heterologous production of secondary metabolite BGCs in …
known secondary metabolites. Heterologous production of secondary metabolite BGCs in …
Engineering the biosynthesis of fungal nonribosomal peptides
Covering: 2011 up to the end of 2021. Fungal nonribosomal peptides (NRPs) and the
related polyketide–nonribosomal peptide hybrid products (PK–NRPs) are a prolific source of …
related polyketide–nonribosomal peptide hybrid products (PK–NRPs) are a prolific source of …
In the fungus where it happens: history and future propelling Aspergillus nidulans as the archetype of natural products research
In 1990 the first fungal secondary metabolite biosynthetic gene was cloned in Aspergillus
nidulans. Thirty years later,> 30 biosynthetic gene clusters (BGCs) have been linked to …
nidulans. Thirty years later,> 30 biosynthetic gene clusters (BGCs) have been linked to …